Effects of post-transplantation cyclophosphamide for prevention of chronic graft-versus-host disease after full HLA-matched allogenic bone marrow transplantation in hematologic malignancies treatment

A Study on the Effect of post-transplantation cyclophosphamide for prevention of chronic graft-versus-host disease following full HLA-matched allogenic bone marrow transplantation in hematologic malignancies treatment

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250418065380N1

Enrollment

Registered

2025-07-08

Start date

2025-05-05

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graft Versus Host Disease. Complications of bone marrow transplant

Interventions

Intervention 1: 1. Intervention Group (Post-Transplant Cyclophosphamide Group – PTCy group) , Description:Patients in this group receive prophylaxis against chronic GVHD using high-dose cyclophospham

Eligibility

Sex/Gender

All

Age

16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients undergoing allogeneic bone marrow transplantation from an HLA-matched donor referred to the Hematology Department of Taleghani Hospital

Exclusion criteria

Exclusion criteria: Severe Renal or Hepatic Dysfunction Pre-existing Cardic Disease Active Uncontrolled Infection Prior Exposure of high-dose alkylating agent Delayed Engraftment or graft failure

Design outcomes

Primary

Measure	Time frame
The incidence and percentage of GVHD following allogeneic bone marrow transplantation. Timepoint: typically after day 100 post-transplant and after that. Method of measurement: Based on the standard questionnaire and scoring system for Graft-versus-Host Disease (GVHD).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSalar Servati

Shahid Beheshti University of Medical Sciences

saliquincer2@gmail.com+98 21 2303 1499

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026