Hypertrophic scar. Hypertrophic scar
Conditions
Interventions
Intervention 1: Intervention group: In this group of scar lesions, polymeric films containing lipid-based nanoparticles loaded with the two drugs 5-fluorouracil and triamcinolone acetonide will be use
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 60 Years
Inclusion criteria
Inclusion criteria: Individuals with at least one hypertrophic scar lesion ranging in size from 0.5 cm to 10 cm
Exclusion criteria
Exclusion criteria: Individuals with systemic diseases Individuals allergic to corticosteroids Pregnant women Individuals with neuropsychiatric disorders who are unable to tolerate maintaining a skin patch for 2 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of hypertrophic scar height. Timepoint: Seven days after the initiation of using the nanoparticle-containing film. Method of measurement: Ruler.;Measurement of hypertrophic scar vascularity. Timepoint: Seven days after the initiation of using the nanoparticle-containing film. Method of measurement: Visual assessment.;Measurement of hypertrophic scar pliability. Timepoint: Seven days after the initiation of using the nanoparticle-containing film. Method of measurement: Palpation.;Assessment of hypertrophic scar pigmentation. Timepoint: Seven days after the initiation of using the nanoparticle-containing film. Method of measurement: Visual assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of changes in pruritus at the site of hypertrophic scar lesions. Timepoint: Even days after the initiation of using the nanoparticle-containing film. Method of measurement: Patient-reported outcomes. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParvin Zakeri-Milani
Tabriz University of Medical Sciences
Outcome results
None listed