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Diltiazem for symptoms of Slow Flow Coronary

Study of the effectiveness of Diltiazem on symptoms in patients with slow flow coronary angiography during a 6-month follow-up; A randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250415065333N1
Enrollment
80
Registered
2025-04-18
Start date
2025-04-26
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Slow coronary flow. Other forms of angina pectoris

Interventions

Intervention 1: Intervention group: In this group, in addition to common medications, patients in the intervention group will be given 60 mg of diltiazem orally every 12 hours as one tablet for six mo

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Diagnostic angiography due to chronic symptoms or a positive non-invasive stress test, in which the contrast agent has not yet reached the end of the coronary arteries despite 3 heartbeats during angiography, or the patient has a TIMI frame count greater than 27 during angiography. No history of MI or prior revascularization

Exclusion criteria

Exclusion criteria: Cardiomyopathy with an ejection fraction below 40%. History of allergy to diltiazem Systolic blood pressure less than or equal to 90 mmHg Moderate or severe valvular heart disease Congenital heart disease Coronary artery stenosis of more than 50% or coronary artery ectasia Bradycardia with a heart rate below 60 Angina pectoris with NYHA classification 3 and 4 2nd and 3rd degree atrioventricular block

Design outcomes

Primary

MeasureTime frame
Clinical symptoms of patients including chest pain, functional chest pain and functional shortness of breath and 6-minute walking test. Timepoint: Six month after the first visit and drug consumption. Method of measurement: Evaluation and questioning of patients by a specialist doctor and registration in the checklist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdolhadi Aref

Tehran University of Medical Sciences

ah-aref@razi.tums.ac.ir+98 21 81631

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026