Migraine. Migraine
Conditions
Interventions
Intervention 1: Intervention group: Moderate-carbohydrate diet (35-40% carbohydrates, 40-45% fat, and 20% protein) with a minimum fiber intake of 25 grams per day. Intervention 2: Control group: The c
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Female, aged 18–45 years BMI between 18.5 and 30 kg/m² Female have been on a stable dose of prophylactic migraine medication for at least one month before enrollment
Exclusion criteria
Exclusion criteria: BMI outside the range of 18.5–30 kg/m² Pregnancy, lactation, menopause, smoking, alcohol abuse Significant medical conditions such as major psychiatric disorders, autoimmune diseases, or chronic gastrointestinal, diabetes, cancer, liver, or kidney diseases Current use of certain medications or supplements, including probiotics, or antibiotics less than one month before the study, or those using CGRP inhibitors, neuroleptics (antidepressants), opioid drugs, thiazide diuretics, glucocorticoids, statins, orlistat, or weight-affecting supplements, dietary supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Migraine Symptoms Assessment. Timepoint: Monthly. Method of measurement: questionnaire.;Serum concentrations of Calcitonin gene-related peptide (CGRP). Timepoint: At the beginning and end of the study. Method of measurement: ELISA kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum concentrations of serotonin and calcitonin gene-related peptide (CGRP). Timepoint: Beginning and end of the study. Method of measurement: ELISA kits.;Gut microbiota assessment including Bifidobacterium, Ruminococcus, Lactobacillus, and the Firmicutes to Bacteroidetes ratio. Timepoint: beginning and end of the study. Method of measurement: Absolute-Real-time-PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeedeh Nouri-Majd
Tehran University of Medical Sciences
Outcome results
None listed