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Effect of GCSF on pregnancy

Comparison of the effectiveness of intrauterine and subcutaneous GCSF administration on pregnancy outcome in freeze transfer cycles

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250413065312N1
Enrollment
195
Registered
2025-07-19
Start date
2025-07-23
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Embryo Transfer. Complications of attempted introduction of embryo in embryo transfer

Interventions

Intervention 1: Control Group:All eligible participants (both intervention and control) received oral estradiol valerate (2 mg
Aburaihan Pharmaceutical Company, Tehran, Iran) at a total daily dose of 6 mg, starting from day 2 or 3 of the menstrual cycle, provided transvaginal ultrasound confirmed an appropriate endometrium an
Aburaihan Pharmaceutical Company, Tehran, Iran). Embryo transfer was then scheduled accordingly. The control group did not receive any additional medications. Intervention 2: Intervention Group 1:Thir

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women ageed 20 to 45 years To have embryo frozen History of one failed frozen embryo transfer HRT embryo transfer cycle

Exclusion criteria

Exclusion criteria: Fresh embryo transfer cycles Frozen embryo transfer for first time Male infertility Patients with endometriosis Presence of hydrosalpinx Presence of a myoma with a compressive effect on the endometrium Presence of endometrial pathology

Design outcomes

Primary

MeasureTime frame
Implantation rate. Timepoint: Four weeks after the embryo transfer. Method of measurement: Transvaginal ultrasound.;Chemical pregnancy. Timepoint: Two weeks after the embryo transfer. Method of measurement: Pregnancy blood test (Serum ß-hCG test).;Clinical pregnancy. Timepoint: Four weeks after embryo transfer. Method of measurement: Transvaginal ultrasound.

Secondary

MeasureTime frame
Multiple pregnancy. Timepoint: Four weeks after embryo transfer. Method of measurement: Transvaginal ultrasound.;Miscarriage. Timepoint: From positive pregnancy test up to 20 weeks of gestation. Method of measurement: Transvaginal ultrasound.;Ectopic pregnancy. Timepoint: From four weeks after embryo transfer. Method of measurement: Transvaginal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshad Forati Kashani

Tehran University of Medical Sciences

dr.foratimahshad@gmail.com+98 21 8490 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026