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Investigating the effects of tDCS combined with computer-based cognitive rehabilitation on cognitive functions in individuals with a-MCI

Investigating the effects of transcranial direct current stimulation (tDCS) combined with computer-based cognitive rehabilitation on brain mapping and cognitive functions in individuals with amnestic mild cognitive impairment (a-MCI)

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250410065281N1
Enrollment
30
Registered
2025-04-19
Start date
2025-04-21
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment. Mild cognitive disorder: A disorder characterized by impairment of memory, learning difficulties, and reduced ability to concentrate on a task for more than brief periods. There is often a marked feeling of mental fatigue when mental tasks are attempted,

Interventions

Intervention 1: Intervention Group: Each individual in this group will undergo intervention over 12 sessions during a period of 4 weeks. The intervention consists of receiving 45 minutes of cognitive

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 75 Years

Inclusion criteria

Inclusion criteria: Individuals with a diagnosis of mild cognitive impairment between the ages of 55 and 75. Being a native Persian speaker Being right-handed Having at least a 5th-grade education Ability to collaborate in all stages of assessment, treatment, and follow-up (EEG acquisition, computerized and paper-pencil cognitive tests, rehabilitation sessions, and brain stimulation with tDCS)

Exclusion criteria

Exclusion criteria: Any uncorrectable defects in visual and auditory senses Presence of any metal implants in the head and chest History of untreated neurological disorders and history of epilepsy History of major psychiatric disorders in the past year function History of cardiovascular, respiratory, and skin diseases History of substance abuse and alcohol consumption Current use of medications affecting brain function Simultaneous participation in another study related to the nervous system and cognitive

Design outcomes

Primary

MeasureTime frame
EEG indicators. Timepoint: Pre and post the intervention. Method of measurement: Complete tools and software for recording and analyzing electroencephalography signals.

Secondary

MeasureTime frame
Cognitive performance in domains related to MCI in CANTAB. Timepoint: Pre and post the intervention. Method of measurement: Scores obtained from performing the MCI-related domains in the CANTAB Computerized Assessment Battery.;Overall cognitive performance in MoCA and Adenbrook tests. Timepoint: Pre and post the intervention. Method of measurement: Score obtained from the performance on the MoCA and Adenbrook pencil-paper tests.;Percentage of accuracy in picture naming. Timepoint: Pre and post the intervention. Method of measurement: Percentage of correctly named items in the picture naming test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamadreza Namavar

Shiraz University of Medical Sciences

namavarm@sums.ac.ir0987132304284

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026