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Effects of Central and Peripheral Stimulation Combined with Exercise in Women with Patellofemoral Pain Syndrome

Synergistic Effects of transcranial Direct Current Stimulation, transcranial Alternative Current Stimulation and Neuromuscular Electrical Stimulation Combined with Exercise Therapy on Clinical Outcomes and Electroencephalographic Activity in Women with Patellofemoral Pain Syndrome

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250408065257N1
Enrollment
42
Registered
2025-05-12
Start date
2025-05-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patellofemoral Pain Syndrome.

Interventions

Intervention 1: Intervention group: NMES and Exercise Therapy. Intervention 2: Intervention group: tDCS and Exercise Therapy. Intervention 3: Intervention group: tACS and Exercise Therapy.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Women Aged Between 18 and 35 Years History of Unilateral or Bilateral Pain Around or Behind the Patella, Exacerbated by at Least Two of the Following Activities: Squatting, Going Up or Down Stairs, or Prolonged Sitting with Knees Bent Tenderness to Palpation Over the Medial or Lateral Facets of the Patella Pain During Isometric Contraction of the Quadriceps Against Resistance Applied Above the Patella, and Pain During Resisted Knee Extension at Various Degrees of Flexion Non-traumatic Onset of Symptoms Patellofemoral Joint Pain for at Least the Past 3 Months Minimum Literacy Level Equivalent to Completion of Middle School

Exclusion criteria

Exclusion criteria: History of Knee Injuries such as Meniscal, Tendon, or Ligament Damage History of Patellar Subluxation or Dislocation Any Condition Affecting Other Joints Involving the Lower Limbs or the Back History of Fractures in the Spine or Lower Limbs History of Surgery or Arthroscopy in any of the Lower Limb Joints History of Head Trauma, Neurological Disorders, or Mental Health Issues Contraindications for Neuromodulation such as Pregnancy, Presence of Metal Implants, Epilepsy, History of Skull Fracture, or Cardiac Pacemaker

Design outcomes

Primary

MeasureTime frame
Pain Intensity on Visual Analogue Scale. Timepoint: Pain intensity will be measured at the beginning of the study (before the start of the intervention), after completing 12 intervention sessions, and one month after the end of the intervention. Method of measurement: Visual Analogue Scale.

Secondary

MeasureTime frame
Functional Activity Level. Timepoint: Functional Activity Level will be measured at the beginning of the study (before the start of the intervention), after completing 12 intervention sessions, and one month after the end of the intervention. Method of measurement: Kujala Questionnaire.;Dynamic Balance. Timepoint: Dynamic Balance will be measured at the beginning of the study (before the start of the intervention), after completing 12 intervention sessions, and one month after the end of the intervention. Method of measurement: Y-balance test.;Functional Performance. Timepoint: Functional Performance will be measured at the beginning of the study (before the start of the intervention), after completing 12 intervention sessions, and one month after the end of the intervention. Method of measurement: Step-Down test.;Mean relative power of the EEG frequency bands. Timepoint: Mean relative power of the EEG frequency bands will be measured at the beginning of the study (before the start of the intervention), after completing 12 intervention sessions, and one month after the end of the intervention. Method of measurement: Recording with an EEG device and measurement using sLORETA software.;Mean absolute power of the EEG frequency bands. Timepoint: Mean absolute power of the EEG frequency bands will be measured at the beginning of the study (before the start of the intervention), after completing 12 intervention sessions, and one month after the end of the intervention. Method of measurement: Recording with an EEG device and measurement using sLORETA software.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira Karimpour

Tehran University of Medical Sciences

karimpour-s@razi.tums.ac.ir+98 21 7753 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026