Coronary artery disease. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group:The intervention group will receive pulsatile perfusion using the Sorin Stockert V roller pump, maintaining a perfusion flow of 2 to 2.8 liters per minute per square
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: All adult patients aged between 40 and 80 years will be included in the study. Patients with a Body Mass Index (BMI) of up to 25 will be included. Patients scheduled for coronary artery bypass grafting (CABG) using the ON-CPB method will be included. Patients who provide written informed consent to participate in the study will be included.
Exclusion criteria
Exclusion criteria: History of re-do cardiac surgery Left ventricular dysfunction with ejection fraction less than 35 percent Liver dysfunction indicated by SGOT or SGPT levels more than 1.5 times the upper normal limit Known coagulation disorders prior to surgery Preoperative renal disease including GFR less than 50 cc/min/1.73m² Emergency cardiac surgery Preoperative hemoglobin less than 10 mg/dl
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal Regional Oxygen Saturation. Timepoint: Before the intervention (prior to induction of anesthesia),During the intervention (cardiopulmonary bypass), every 15 minutes till Sixty minutes after the end of the intervention (cardiopulmonary bypass). Method of measurement: using a Near-Infrared Spectroscopy (NIRS) device. The dedicated probe will be placed on the patient’s flank (posterior renal area), and oxygen saturation values will be continuously recorded in percentage units (%). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Urea Nitrogen (BUN). Timepoint: Before the intervention, Immediately after the intervention,24 hours after the intervention. Method of measurement: Using blood samples and either a spectrophotometer or a biochemical analyzer.;Serum Creatinine (Cr). Timepoint: Before the intervention, Immediately after the intervention,24 hours after the intervention. Method of measurement: Using blood samples and spectrophotometer or Biochemistry Analyzer.;Glomerular Filtration rate. Timepoint: Before the intervention,Immediately after the intervention ,24 hours after the intervention,48 hour after the intervention. Method of measurement: Glomerular Filtration Rate = ? {(140 - {Age }) *{Weight in kilograms}*{Gender factor}}/{72 *{Serum creatinine in milligrams per deciliter}} ? where the gender factor is 1 for males and 0.85 for females.;Serum sodium level. Timepoint: Before the intervention,Immediately after the intervention ,24 hours after the intervention. Method of measurement: using a blood sample and Electrolyte Analyzer and Ion meter devices.;Serum glucose level. Timepoint: Before the intervention,Immediately after the intervention ,24 hours after the intervention. Method of measurement: measured using a biochemical analyzer and the enzymatic glucose oxidase method.”.;Erythrocyte Sedimentation Rate (ESR). Timepoint: Before the intervention ,24 hours after the intervention. Method of measurement: ESR was measured using the Westergren method and a venous blood sample.;Vasopressor- Inotropic score. Timepoint: Immediately after the intervention, 6 hours after the intervention,24 hours after the intervention,48 hours after the intervention. Method of measurement: Vasopressor- Inotropic score = ([Dopamine+ Dobutamin] ×1) + (Milrinone×15 | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Asghar Moeinipour
Mashhad University of Medical Sciences
Outcome results
None listed