Effects of eight weeks of aerobic exercise and vitamin E supplementation in women with depressive symptoms.

Effects of 8 Weeks of Aerobic Training and Vitamin E supplementation on Interleukin-6, Depression Severity, and Some Psychological indicators in Women with Signs of Depression

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250402065189N1

Enrollment

Registered

2025-06-25

Start date

2025-07-06

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression. Major depressive disorder, single episode, mild

Interventions

Intervention 1: Intervention group: Continuous aerobic exercise, including 3 weekly training sessions for 8 weeks. In the first week, the exercises will be performed for 20 minutes at an intensity of

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: ?Age range 18 to 50 years Body mss index (BMI) less than 29/9 kg/m2 Having depressive symptoms (score of 16 or higher on the Center for Epidemilogical Studies Depression Scale)

Exclusion criteria

Exclusion criteria: presence of musculoskeletal abnormalities or disorder participation in a regular exercise in the past 6 months Taking supplements with anti-inflammatory properties

Design outcomes

Primary

Measure	Time frame
Change in serum levels of Interleukin 6. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: Blood sampling, Serum measurement by ELYSA method.;Change in severity of Depression. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: The Center for Epidemiologic Studies-Depression (CES-D) scale.	—

Measure

Time frame

Change in serum levels of Interleukin 6. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: Blood sampling, Serum measurement by ELYSA method.;Change in severity of Depression. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: The Center for Epidemiologic Studies-Depression (CES-D) scale.

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Secondary

Measure	Time frame
General fatigue assessment. Timepoint: Before the start of the intervention and 8 weeks after the start of the intervention. Method of measurement: Multidimensional Fatigue Index (MFI).;Body image. Timepoint: Before the start of the intervention and 8 weeks after the start of the intervention. Method of measurement: 9-item physical-social anxiety scale and the Multidimensional Body self-Relation Questionnaire (MBSRQ).;Dementia. Timepoint: Before the start of the intervention and 8 weeks after the start of the intervention. Method of measurement: Ascertain Dementia 8 Questionnaire (AD8).;Change in Cognitive flexibility. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: Cognitive Flexibility Questionnaire.;Change in Anxiety intensity. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: Hamilton Anxiety Rating Scale.	—

Measure

Time frame

General fatigue assessment. Timepoint: Before the start of the intervention and 8 weeks after the start of the intervention. Method of measurement: Multidimensional Fatigue Index (MFI).;Body image. Timepoint: Before the start of the intervention and 8 weeks after the start of the intervention. Method of measurement: 9-item physical-social anxiety scale and the Multidimensional Body self-Relation Questionnaire (MBSRQ).;Dementia. Timepoint: Before the start of the intervention and 8 weeks after the start of the intervention. Method of measurement: Ascertain Dementia 8 Questionnaire (AD8).;Change in Cognitive flexibility. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: Cognitive Flexibility Questionnaire.;Change in Anxiety intensity. Timepoint: Before the start of the intervention, and 8 weeks after the start of the intervention. Method of measurement: Hamilton Anxiety Rating Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRostam Alizadeh

Ilam University

Alizadeh.rostam@gmail.com+98 84 5592 4120

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026