comparison of the effects of skin preparation using a combination of 10% Betadin and 70% isopropyl alcohol versus 10% Betadin alone on microbial load and surgical site infection in abdominal patients

comparison of the effects of skin preparation using a combination of 10% povidone-iodine and 70% isopropyl alcohol versus 10% povidone-iodine alone on microbial load and surgical site infection in laparotomy patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250329065171N1

Enrollment

Registered

2025-04-09

Start date

2025-04-09

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

surgical site infection. Bacterial infection, unspecified

Interventions

Intervention 1: Intervention group: Skin preparation of the surgical site using a combination of 10% povidone-iodine and 70% isopropyl alcohol. Intervention 2: Control group: Skin preparation of the s

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Elective surgery Age 18 to 55 years Absence of underlying diseases (immune system suppressing diseases, diabetes, lupus, etc.) No history of laparotomy surgery Body Mass Index (BMI) less than 35 Absence of local infection near the surgical site or systemic infection No allergy to povidone-iodine antiseptic No history of malignancy and radiotherapy Absence of severe skin rash at the surgical site No use of broad-spectrum antibiotics within one month prior to hospital admission Having at least a high school diploma

Exclusion criteria

Exclusion criteria: An occurrence of a disruption in the surgical process that leads to the contamination of surgical instruments or the surgical environment.

Design outcomes

Primary

Measure	Time frame
The microbial load of the skin at the surgical site after initial and secondary preparation. Timepoint: Microbial culture at the time before surgery, after initial preparation, after secondary preparation. Method of measurement: Researcher-developed form for recording the microbial load.;The rate of post-operative infection (after the first 24 hours). Timepoint: Investigation of signs of infection 24 hours after surgery. Method of measurement: Researcher-developed form for recording signs of surgical site infection.;The rate of post-operative infection (after 30 days). Timepoint: Investigation of signs of infection during the 30 days following surgery. Method of measurement: Researcher-developed form for recording signs of surgical site infection.	—

Measure

Time frame

The microbial load of the skin at the surgical site after initial and secondary preparation. Timepoint: Microbial culture at the time before surgery, after initial preparation, after secondary preparation. Method of measurement: Researcher-developed form for recording the microbial load.;The rate of post-operative infection (after the first 24 hours). Timepoint: Investigation of signs of infection 24 hours after surgery. Method of measurement: Researcher-developed form for recording signs of surgical site infection.;The rate of post-operative infection (after 30 days). Timepoint: Investigation of signs of infection during the 30 days following surgery. Method of measurement: Researcher-developed form for recording signs of surgical site infection.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactYosef Abdolmaleki

Iran University of Medical Sciences

yosefabdolmaleki.st@gmail.com+98 21 8670 4600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026