placental insufficiency. Maternal care for known or suspected placental insufficiency, third trimester
Conditions
Interventions
Intervention 1: Control group: In this group, mothers receive low-dose aspirin, 160 mg daily, from 12 to 36 weeks of pregnancy, according to national and international protocols, due to a history of o
Sponsors
Yasouj University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: single tone pregnancy past history of placental insufficiency no allergic reaction to Hydroxychloroquine no recent use of Hydroxychloroquine no retinopathy in mothers older than 40 y/o
Exclusion criteria
Exclusion criteria: past history of autoimmune and rheumatoid disease past history of hypertension or diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Birth weight. Timepoint: Immediately after birth. Method of measurement: hospital scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| NICU Admission. Timepoint: Immediately after birth until discharge. Method of measurement: Hospital records and NICU records.;Preeclampsia. Timepoint: Initially, at the first prenatal visit before 12 weeks and before the start of the intervention, and then every 4 weeks until week 28, every 2 weeks from 28 to 36 weeks, and weekly from 36 weeks until delivery, and an assessment is made at each visit. Method of measurement: Mercury or digital sphygmomanometer, dipstick urine test, 24-hour proteinuria, clinical symptom checklist.;Gestational hypertension. Timepoint: Initially, at the first prenatal visit before 12 weeks and before the start of the intervention, and then every 4 weeks until week 28, every 2 weeks from 28 to 36 weeks, and weekly from 36 weeks until delivery, and an assessment is made at each visit. Method of measurement: Mercury or digital sphygmomanometer, recorded in maternal record.;Placental abruption. Timepoint: Initially, at the first prenatal visit before 12 weeks and before the start of the intervention, and then every 4 weeks until week 28, every 2 weeks from 28 to 36 weeks, and weekly from 36 weeks until delivery, and an assessment is made at each visit. Method of measurement: Ultrasound, patient record, clinical examination based on American College of Obstetricians and Gynecologists criteria.;Intrauterine growth restriction. Timepoint: From the 20th week of pregnancy (8 weeks after the start of the intervention) every 2 to 4 weeks until delivery. Method of measurement: Ultrasound, maternal medical record, standard fetal growth curves based on ACOG criteria.;Preterm labor. Timepoint: From the 20th week of pregnancy (8 weeks after the start of the intervention) every 2 to 4 weeks until delivery. Method of measurement: Maternal medical record and study registration.;APGAR score at 1 and 5 minute. Timepoint: 1 and 5 minutes after birth. Method of measurement: Standard APGAR form. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRazie Vanda
Yasouj University of Medical Sciences
Outcome results
None listed