Comparison of the Effect of Probiotic Lactobacillus reuteri and Antibiotic in Smokers with Periodontitis

Comparison of the Effect of Systemic Use of Lactobacillus Reuteri Probiotic and Antibiotic as a Supplement to Non –Surgical Periodontal Treatment in Smokers Patients with Stage IV-II Grade B Periodontitis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250319065129N1

Enrollment

Registered

2025-05-25

Start date

2025-05-06

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis, generalized

Interventions

Intervention 1: Intervention group: probiotic supplement (BSK PYLOSHOT) twice daily after tooth brushing (morning and night) for 21 days. They are instructed to avoid using any probiotic-containing pr

Eligibility

Sex/Gender

All

Age

35 Years to 70 Years

Inclusion criteria

Inclusion criteria: Heavy smokers (more than 10 cigarettes per day for more than 5 years) CAL) greater than 3 mm, with clinical signs of gingival inflammation such as erythema and BOP Systemically healthy patients Patients with more than 15 teeth No history of periodontal treatment in the past 6 months No antibiotic treatment in the past 3 months No use of NSAIDs in the past 2 weeks No probiotic supplementation in the past 6 months Absence of systemic diseases or conditions that interfere with wound healing Absence of inflammatory conditions in the oral mucosa, such as aphthous ulcers, lichen planus, or acute hypersensitivity reactions No use of medications affecting the periodontium (e.g., anticonvulsants, calcium channel blockers, or immunosuppressants) Not undergoing radiotherapy Not pregnant, breastfeeding, or using hormonal medications

Exclusion criteria

Exclusion criteria: Non-compliance with the prescribed oral probiotic or antibiotic regimen

Design outcomes

Primary

Measure	Time frame
Gingival bleeding index. Timepoint: At the beginning of the study and 90 days after the intervention. Method of measurement: Periodontal pocket probing depth measured by the investigator.;Clinical attachment loss. Timepoint: At the beginning of the study and 90 days after the intervention. Method of measurement: Periodontal pocket probing depth measured by the investigator.;Probing depth. Timepoint: At the beginning of the study and 90 days after the intervention. Method of measurement: Periodontal pocket probing depth measured by the investigator.	—

Measure

Time frame

Gingival bleeding index. Timepoint: At the beginning of the study and 90 days after the intervention. Method of measurement: Periodontal pocket probing depth measured by the investigator.;Clinical attachment loss. Timepoint: At the beginning of the study and 90 days after the intervention. Method of measurement: Periodontal pocket probing depth measured by the investigator.;Probing depth. Timepoint: At the beginning of the study and 90 days after the intervention. Method of measurement: Periodontal pocket probing depth measured by the investigator.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajad Farrokhi

Oroumia University of Medical Sciences

S.farrokhi007@gmail.com+98 44 3365 0729

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026

Comparison of the Effect of Probiotic *Lactobacillus reuteri* and Antibiotic in Smokers with Periodontitis