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Evaluation of the effect of human amniotic membrane on the level of pain, swelling and maximum mouth opening in patients after surgery of impacted lower jaw's wisdom tooth

Evaluation of the effect of human amniotic membrane on the level of pain, swelling and trismus in patients after surgery of impacted mandibular third molar

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250318065121N1
Enrollment
19
Registered
2025-06-27
Start date
2025-05-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted teeth. Impacted teeth

Interventions

Intervention 1: Intervention group: Cryopreserved amniotic membrane from a company is prepared. It is in a micronized gel form, stored in 2cc syringes at -20°C. These syringes are aseptically steriliz

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Patients with bilateral impacted mandibular third molar Impaction with a mesioangular postition on both sides

Exclusion criteria

Exclusion criteria: Patients with any systemic disease and pregnant women Patients taking any anticoagulant or antihypertensive medications, and those receiving blood products Presence of pericoronitis or its symptoms in the past 30 days Smokers

Design outcomes

Primary

MeasureTime frame
Swelling. Timepoint: Days 7,2,0(before surgery). Method of measurement: Swelling measurement is performed using a series of points. These points include:1)Horizontal distance between the lower edge of the ear to the midpoint of the chin in millimeters.2)Horizontal distance between the lower edge of the ear to the external angle of the mouth in millimeters.3)Vertical distance from the outer border of the palpebral angle to the gonial angle in millimeters. All three points are measured before surgery, and then these points are measured again after surgery.;Pain. Timepoint: Days 0,2 and 7 after surgery. Method of measurement: Pain measurement using the Numerical Pain Rating Scale method will be performed numerically, ranging from zero to ten. After receiving the necessary explanations, the patient is given a scale with numbers ranging from zero to ten and marks the number that corresponds to their pain level. Zero indicates no pain, and ten indicates the most severe pain. Pain measurement is conducted on days zero, two, and seven, with pain recorded on the day of surgery (day zero) six hours post-surgery.;Trismus. Timepoint: Days 7,2,0(before surgery). Method of measurement: Trismus measurement is based on the maximum distance between the incisors. The measurement times are days 0, 2, and 7, during which the patient visits the surgery department of the dental school, and the measurements are taken by a dentist. The measurement on the day of surgery (day zero) is taken before the surgery.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Hashemi

Tabriz University of Medical Sciences

Mohsen.hashemi3263@gmail.com+98 41 3334 6977

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026