Studying the effectiveness of collagen cross-linking (CXL) in patients with keratoconus (KCN)

Evaluation of the safety and efficacy of collagen cross-linking (CXL) in children and young adults with keratoconus(KCN)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250315065091N1

Enrollment

Registered

2025-10-16

Start date

2025-06-03

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

keratoconus. Keratoconus

Interventions

After taking a complete medical history including underlying disease, atopy history, and history of previous ophthalmological procedures, patients undergo ophthalmological examinations including slit-

Eligibility

Sex/Gender

All

Age

No minimum to 22 Years

Inclusion criteria

Inclusion criteria: kerqtoconus Children and young adults Minimum corneal thickness =400µm

Exclusion criteria

Exclusion criteria: Severe dry eye Paracentral or central corneal opacity Autoimmune disease Active corneal infection History of herpetic keratitis

Design outcomes

Primary

Measure	Time frame
Uncorrected visual acuity. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Snellen chart.;Best corrected visual acuity. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Snellen chart.;Intraocular pressure. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Goldmann applanation tonometer.;Refraction. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: refractometer.;Corneal cell density . Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Specular microscopy.	—

Measure

Time frame

Uncorrected visual acuity. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Snellen chart.;Best corrected visual acuity. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Snellen chart.;Intraocular pressure. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Goldmann applanation tonometer.;Refraction. Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: refractometer.;Corneal cell density . Timepoint: At intervals of one month, three months, six months, and twelve months. Method of measurement: Specular microscopy.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaadi Rahmani

Iran University of Medical Sciences

saadirahmani90@gmail.com+98 21 8838 6136

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026