Studying the effect of a combination of oxytocin and tranexamic acid on postpartum hemorrhage

A Study on the Effect of the Combination of Oxytocin and Tranexamic Acid Compared to the Use of Oxytocin on on patients with Postpartum Hemorrhage.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250315065085N1

Enrollment

320

Registered

2025-04-17

Start date

2025-05-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Natural childbirth.

Interventions

Intervention 1: Intervention group: Intravenous injection of tranexamic acid serum dissolved in normal saline + oxytocin. Intervention 2: Control group: Normal saline + oxytocin.

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pregnant with a singleton Active form of pregnancy No contraindications for natural childbirth Informed consent

Exclusion criteria

Exclusion criteria: Caesarean operation Contraindications for childbirth Postpartum bleeding History of internal disease Unwillingness to participate in the study Multiple birth

Design outcomes

Primary

Measure	Time frame
Age. Timepoint: Before the intervention begins. Method of measurement: Questionnaire.;BMI. Timepoint: Before the intervention begins. Method of measurement: Questionnaire.;Vital signs. Timepoint: Athe intervention begins. Method of measurement: Questionnaire.;Number of pregnancies. Timepoint: Before the intervention begins. Method of measurement: Questionnaire.;Blood pressure. Timepoint: Before and after the intervention began. Method of measurement: Case review.;Heart rate. Timepoint: before and after the intervention. Method of measurement: Case review.;Hemoglobin. Timepoint: 24 and 12 hours before and after the intervention. Method of measurement: Blood test.;Hematocrit. Timepoint: 24 and 12 hours before and after the intervention. Method of measurement: Blood test.;Duration of hospitalization. Timepoint: ???After the intervention. Method of measurement: Case review.;Drug side effects. Timepoint: ??After the intervention. Method of measurement: Case review.;Need for additional treatment. Timepoint: ???After the intervention. Method of measurement: Case review.	—

Measure

Time frame

Age. Timepoint: Before the intervention begins. Method of measurement: Questionnaire.;BMI. Timepoint: Before the intervention begins. Method of measurement: Questionnaire.;Vital signs. Timepoint: Athe intervention begins. Method of measurement: Questionnaire.;Number of pregnancies. Timepoint: Before the intervention begins. Method of measurement: Questionnaire.;Blood pressure. Timepoint: Before and after the intervention began. Method of measurement: Case review.;Heart rate. Timepoint: before and after the intervention. Method of measurement: Case review.;Hemoglobin. Timepoint: 24 and 12 hours before and after the intervention. Method of measurement: Blood test.;Hematocrit. Timepoint: 24 and 12 hours before and after the intervention. Method of measurement: Blood test.;Duration of hospitalization. Timepoint: ???After the intervention. Method of measurement: Case review.;Drug side effects. Timepoint: ??After the intervention. Method of measurement: Case review.;Need for additional treatment. Timepoint: ???After the intervention. Method of measurement: Case review.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactghazal Mansouri

Kerman University of Medical Sciences

Dr_mansouri93@yahoo.com+98 34 3244 9049

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026