The Effect Of Empagliflozin On Kidney Stones

Investigating The Effect Of Empagliflozin On Oxidative Stress And Inflammatory Markers And Random Urine Indicators In Patients With Kidney Stones: A Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250314065068N1

Enrollment

Registered

2025-04-27

Start date

2025-05-05

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrolythiasis. Calculus of kidney

Interventions

Intervention 1: Intervention group: Empagliflozin (10 mg), Daily, After Breakfast, For 2 Weeks. Intervention 2: Control group: A Placebo Will Be Used for the Control Group.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The Presence Of Kidney Stones Less Than 6 Millimeters. The Absence Of Secondary Causes Of Recurrent Nephrolithiasis.

Exclusion criteria

Exclusion criteria: The Presence Of Severe Eating Disorders.. The Presence Of Sarcoidosis.

Design outcomes

Primary

Measure	Time frame
Interleukin-6. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Total Antioxidant Capacity of Plasma. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Superoxide Dismutase. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Malondialdehyde. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Glutathione Peroxidase Activity. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;C-Reactive Protein. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Tumor Necrosis Factor-alpha (TNF-a). Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Random Urine Creatinine. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Random Urine Uric Acid. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.	—

Measure

Time frame

Interleukin-6. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Total Antioxidant Capacity of Plasma. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Superoxide Dismutase. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Malondialdehyde. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Glutathione Peroxidase Activity. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;C-Reactive Protein. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Tumor Necrosis Factor-alpha (TNF-a). Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Random Urine Creatinine. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.;Random Urine Uric Acid. Timepoint: Before And Immediately After The Research Intervention. Method of measurement: Lab Kit.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Razazan

Yasouj University of Medical Sciences

m_razazan@yahoo.com+98 74 3323 5153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026