Premature ovarian failure (POF). Primary ovarian failure
Conditions
Interventions
Intervention 1: The intervention group received routine infertility treatment along with autologous platelet-rich plasma (PRP) injection. Blood was collected from each patient, and PRP was prepared un
Sponsors
Sanandaj University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: The study population included women aged 18–40 years who referred to the infertility centers of Besat Hospital and Dr. Masoumeh Rezaei Clinic during 2025–2026. They were diagnosed with premature ovarian failure (POF) based on laboratory and ultrasound findings, with AMH levels below 1. No male factor infertility was present, and all participants were in good general health.
Exclusion criteria
Exclusion criteria: Patients with platelet function disorders, hematologic diseases, or severe drug hypersensitivity were excluded from the study. Exclusion also applied to those with persistent use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the last 48 hours Patients with active infection or febrile illness at the time of the study, and individuals taking medications that could interfere with treatment or test results. Patients with endocrine or metabolic disorders, as well as those diagnosed with polycystic ovary syndrome (PCOS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oocyte quality. Timepoint: Before the ovarian stimulation protocol and approximately 36 hours after HCG injection and follicular aspiration. Method of measurement: Oocyte quality was evaluated using a microscope after removal of granulosa cells.;Number of mature oocytes. Timepoint: Approximately 36 hours after HCG injection and follicular aspiration. Method of measurement: The number of mature oocytes was determined based on the Metaphase II stage.;Infertility treatment success rate. Timepoint: After intracytoplasmic sperm injection and follow-up of clinical outcomes. Method of measurement: Fertilization rates and pregnancy outcomes were recorded and followed up. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzra Allah Weisi
Sanandaj University of Medical Sciences
Outcome results
None listed