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Effect of L-carnitine in schizophrenia

Investigating the effect of adding L-carnitine to antipsychotic drugs on positive and negative symptoms of schizophrenia patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250310065015N1
Enrollment
60
Registered
2025-05-03
Start date
2025-04-19
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Schizophrenia

Interventions

Intervention 1: Intervention group: Under the treatment of L-carnitine daily one gram in addition to Antipsychotic. Intervention 2: Control group: Antipsychotic treatment with placebo.

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Diagnosed with schizophrenia Age group 25 to 50 years Not having other psychiatric diseases and mental retardation Not having other chronic internal diseases or chronic or acute neurological diseases Not receiving any type of antidepressant or anticonvulsant Lack of dependence on alcohol and other substances Are not pregnant Not during breastfeeding

Exclusion criteria

Exclusion criteria: In case of the onset of any type of internal, neurological or psychiatric disease after entering the study Refusal to continue cooperation The occurrence of any type of drug allergy

Design outcomes

Primary

MeasureTime frame
Negative Symptoms. Timepoint: Before starting the treatment and in weeks 4, 6 and after the end of the 12 week treatment period. Method of measurement: With WSCT, PANSS and Stroop Test.;Positive Symptoms. Timepoint: Before starting the treatment and in weeks 4, 6 and after the end of the 12 week treatment period. Method of measurement: With WSCT, PANSS and Stroop Test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArash Askari Noghani

Mashhad University of Medical Sciences

Arash7askari@gmail.com0098 51 5137112701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026