Pain and wound healing after tooth extraction.
Conditions
Interventions
Intervention 1: Intervention group: For the study group, bromelain capsules (500 mg, Tasnim Pharmaceutical Company, Tehran, Iran) were administered once daily for 10 days, starting on the day of tooth
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligible patients requiring extraction of mandibular molars that have identical tooth situation on both sides will be included in the study after obtaining informed and written consent.
Exclusion criteria
Exclusion criteria: Individuals who take exogenous corticosteroids, vitamin E tablets, and anticoagulant drugs such as aspirin. Individuals with possible sensitivity to pineapple fruit, systemic disorders, respiratory and digestive diseases (GI, renal, and pulmonary), pregnant women and nursing mothers, systemic fungal infections, acute infections, and tuberculosis (active or dormant) will be excluded from the study. Individuals who have used painkillers or anti-inflammatories in the week leading up to surgery will be excluded from the study. Also, patients who smoke, drink, and use drugs, and have tooth symptoms in the week leading up to its extraction will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pain intensity after tooth extraction (based on the VAS scale at various time intervals) 2. Tissue healing 3. Tissue color. Timepoint: Time Points and Frequency of Outcome Assessment in Relation to the Intervention: 1. Before the intervention: Prior to tooth extraction, baseline patient information (such as medical history) is recorded. 2. During the intervention: After tooth extraction, the study group receives Bromelain capsules, while the control group receives a placebo. 3. Days 3, 7, and 14 post-intervention: Evaluation of **pain intensity (VAS scale), wound characteristics, tissue color, palpation response, and presence of granuloma. 4. 72 hours post-intervention: Assessment of pain intensity at intervals of 1, 6, 12, 24, 48, and 72 hours after tooth extraction. 5. Three days post-intervention: Examination for clinical signs of dry socket and, if persistent pain is present, evaluation for alveolar osteitis. 6. Two weeks after intervention completion: Final assessment of tissue healing process. Method of measurement: Visual Analog Scale/Pulse Oximeter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReza Ghanavati
Islamic Azad University
Outcome results
None listed