Alopecia areata (AA) is an autoimmune disorder. Patient presenting with hairless baldness together with healthy skin and conserved follicular ostia. Hairs with exclamations mark and a test of positive pull are done to confrm diagnosis . Yellow spots can been seen on dermoscopy. Spared white hairs
Conditions
Interventions
Intervention Groups Record 1:Group A (Intervention Group)
Sponsors
Shaheed mohtarma benazir bhutto medical university larkana
Eligibility
Sex/Gender
All
Age
12 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patient age between 12-50 years of both genders. Patient diagnosed with alopecia areata.
Exclusion criteria
Exclusion criteria: Patient having SALT score < 50 at baseline Patient with autoimmune diseases Pregnant women Patient's on immunosuppression therapy. Non-consenting patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome in patients with alopecia areata after treatment with intralesional (I/L) triamcinolone and tacrolimus in a randomized clinical trial typically involves assessing hair regrowth. Using trichoscan that analyzes hair density, thickness, and regrowth and taking standardized photographs of the affected area at baseline and follow-up visits to visually assess hair regrowth.Hair regrowth scoring as SALT (Severity of Alopecia Tool) score. Timepoint: Patient is assessed ,before intervention and at 3,6,9,12 weeks after intervension. Method of measurement: Score based on SALT can be calculated using the measurement of the total percentage of hairs that are lost in four areas of the scalp — In the rightside profile (it accounts for 18% of the total area in the scalp), the left side profile (which also accounts for 18% of the total area in the scalp), at the vertex areas (40% of the total area of the scalp), and the posterior (24% of the total area of the scalp), as shown in the figure below. By including total percentage of hairs that are lost in each area are multiplied by the regions relative area, one attains a composite score total i.e the Score of SALT. The regrowth of the hair can be achieved through decreasing the SALT score (e.g, The SALT score can be consider 0 if there is complete hair regrowth. There is a simple tool for the calculation of SALT score based on loss of hair in each of the above mentioned areas.Online SALT score is available to predict hair regrow with treatment . | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Monitoring & documenting adverse effects related to the treatment ,skin irritation,bleeding ,scaring,telangiectasia. Timepoint: Patient will assessed at 3,6,9,12 weeks after intervension. Method of measurement: Patient self-report: patient will be asked to report any discomfort,such as skin irritation,dryness,or allergic reactions during follow up vists. Clinical observation:inspect the treated areas for signs of adverse reactions sach as redness ,swelling or peeling. Efficacy will be assesed using the same parameters as the intervension group: improvement in clinical signs, presence of initially soft hairs regrow followed by pigmented hairs. | — |
Countries
Pakistan
Contacts
Public ContactDr Irfan shaikh
Shaheed mohtarma benazir bhutto medical university larkana
Outcome results
None listed