Comparison of the Effects of Ondansetron and Naloxone on the Improvement of Pruritus Induced by Intrathecal Opioid Use in Patients Undergoing Spinal Anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250306064951N1

Enrollment

Registered

2025-06-08

Start date

2025-09-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(spinal anesthesia). Carpal tunnel syndrome

Interventions

Intervention 1: Intervention group: Ondansetron group: This group is considered as the intervention group that receives the drug ondansetron. Intervention 2: Control group: Naloxone group receives the

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age: Adult patients (18 years and older). 2. Type of operation: Patients undergoing spinal anesthesia (estimated duration of surgery up to 2 hours). 3. Narcotic itching: Patients with itching caused by the use of intrathecal narcotics.

Exclusion criteria

Exclusion criteria: Patients with a history of illness associated with skin itching.

Design outcomes

Primary

Measure	Time frame
Incidence and severity of itching. Timepoint: Before surgery, during surgery, and the recovery period. Method of measurement: Itching measurement: Use of a visual analog scale.	—

Secondary

Measure	Time frame
Nausea and vomiting. Timepoint: Before surgery, during surgery, and the recovery period. Method of measurement: A questionnaire or checklist to record the amount of nausea and vomiting.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFrank Rahtabnak

Iran University of Medical Sciences

Bahrami.ghasem50@gmail.com+98 21 86701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026