Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention group: intraarticlar injection of PRP in knee.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: People between 40 and 80 years old. People with knee pain who have a VAS score of at least 4 on a standing knee radiograph and at least grade 2 osteoarthritis according to the Kellogg-Lawrence criteria, and who have received supportive treatment for at least 3 months and have not responded to treatment.
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Active cancer active infectious disease Drug or drug addiction History of any knee surgery or major trauma (leading to traumatic injury to the ligaments or meniscus or articular cartilage) Blood and coagulation diseases and use of anticoagulants Known rheumatological disease and fibromyalgia Use of anti-inflammatory medications and supplements (NSAIDs, corticosteroids, vitamins E and C, curcumin, and omega-3) within a week before and after the injection Having a significant physical or mental illness that increases the risk of disruption to the study process History of receiving corticosteroids or PRP in the knee for at least the past 6 months Use of any analgesics and physiotherapy modalities within 72 hours prior to outcome assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC questionnaire score. Timepoint: First visit, two months, and 6 months after the second injection. Method of measurement: WOMAC questionnaire.;Pain(VAS). Timepoint: First visit, two months, and 6 months after the second injection. Method of measurement: Patients are asked to rate the overall pain intensity they experienced over the past 48 hours on a Visual Analogue Scale (VAS) from 1 to 100. | — |
Secondary
| Measure | Time frame |
|---|---|
| The 30 Second Sit to Stand Test. Timepoint: First visit and two months after the second injection. Method of measurement: the number of times a person can stand and sit without using the arm of a chair in 30 seconds.;40 metre fast-paced walk test. Timepoint: First visit and two months after the second injection. Method of measurement: The time it takes for a person to walk a distance of 40 meters at maximum speed without running. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeideh Soltani
Tehran University of Medical Sciences
Outcome results
None listed