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Studying the effect and effectiveness of carboxytherapy on rosacea compared to topical metronidazole gel.

: Comparison of efficacy of carboxytherapy and topical metronidazole gel 0.75% in management of rosacea: a controlled randomized 2-split single blind clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250304064933N1
Enrollment
28
Registered
2025-03-09
Start date
2025-04-04
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rosacea. Other rosacea

Interventions

Intervention group: Intervention group: The volunteers' faces are divided into two equal parts, right and left, and the intervention area is determined by tossing a coin. The other side is treated wit
and it is emphasized that in case of any irritation, they should stop using the drug until the skin recovers. In the carboxytherapy area, the treatment continues once every two weeks for up to 5 sessi
In addition, if the needle becomes dull, we replace it with a new one. The patient is advised to avoid washing the area for 24 hours after the treatment to prevent edema. Participants are monitored fo

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient consent to participate in the study Age>15 Presence of rosacea lesions in the facial area, relatively symmetrical on both sides Both sexes

Exclusion criteria

Exclusion criteria: Absence of medication (including dietary supplements) for 6 weeks prior to study start Avoid simultaneous use of systemic and topical medications to treat rosacea lesions. Absence of connective tissue diseases or genodermatoses Lack of tendency to form keloids No smoking, alcohol, or drug abuse Not pregnant Not breastfeeding Not having any systemic diseases such as diabetes, kidney diseases, heart diseases, respiratory diseases, liver diseases, severe anemia, etc.

Design outcomes

Primary

MeasureTime frame
Papule assessment: The number of papules is counted at time zero, before each session, and two weeks after the last session and recorded on a special patient information form. Timepoint: Time zero (before the start of the study), before each session, and two weeks after the last session. Method of measurement: Photographing each half of the face.;Pustule assessment: The number of pustules is counted at time zero, before each session, and two weeks after the last session and recorded on a special patient information form. Timepoint: Time zero (before the start of the study), before each session, and two weeks after the last session. Method of measurement: Photographing each half of the face.;Pustule assessment: The number of pustules is counted at time zero, before each session and two weeks after the last session and recorded in a special patient information form. - Erythema assessment: The extent of erythema is assessed at time zero, before each session and two weeks after the last session and recorded in a special patient information form. For this purpose, the scoring system in Table 1 is used. Table 1: Scoring system for erythema assessment (11) 0: Absence of erythema I (mild): Brief erythema, limited to central or generalized involvement of the entire face II (moderate): Intensified erythema limited to the central or generalized involvement of the entire face III (severe): Severe erythema involving the entire face. Timepoint: Time zero (before the start of the study), before each session, and two weeks after the last session. Method of measurement: Photographing each half of the face.;- Telangiectasia assessment: The extent of telangiectasia is assessed at time zero, before each session and two weeks after the last session and recorded in a special patient information form. For this purpose, the scoring system in Table 2 is used .Table 2: Scoring system for assessing telangiectasia(11)0: Absence of telangiectasia I (mild): Fine vessels smaller than 0.2 mm with

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Abaee Hezaveh

Arak University of Medical Sciences

alireza171299@gmail.com+98 86 3222 9289

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026