"Comparison of the Effects of Dapagliflozin and Empagliflozin on the Incidence of Premature Atrial and Ventricular Contractions in Patients Undergoing Coronary Artery Bypass Graft Surgery

"Comparison of the Effects of Dapagliflozin and Empagliflozin on the Incidence of Premature Atrial and Ventricular Contractions in Patients Undergoing Coronary Artery Bypass Graft Surgery at Imam Khomeini and Golestan Hospitals in Ahvaz

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250302064896N3

Enrollment

Registered

2025-08-10

Start date

2025-08-22

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Atrial premature depolarization. Condition 2: Ventricular premature depolarization. Atrial premature depolarization Ventricular premature depolarization

Interventions

Intervention 1: Intervention group:Intervention Group 1: Patients in this group will receive 10 mg of oral dapagliflozin tablets daily. Administration will begin 48 hours before coronary artery bypass

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients undergoing elective Coronary Artery Bypass Grafting (CABG). Patients aged between 18 and 70 years who are candidates for CABG.

Exclusion criteria

Exclusion criteria: Patients with left ventricular (LV) dysfunction Patients with left atrial (LA) enlargement Patients with chronic kidney disease (CKD) and glomerular filtration rate (GFR) below 30 Patients with a history of atrial fibrillation (AF) Patients with chronic obstructive pulmonary disease (COPD) Patients with a history of urinary tract infection (UTI) Patients with liver failure Patients with mitral valve (MV) disease of more than moderate severity Patients with BMI over 30 Patients sensitive to empagliflozin and dapagliflozin

Design outcomes

Primary

Measure	Time frame
Incidence of premature atrial contractions (PAC) and premature ventricular contractions (PVC) within 72 hours after coronary artery bypass graft surgery. Timepoint: The time points of measurement are within 72 hours after coronary artery bypass graft surgery. Method of measurement: The variable is measured using continuous ECG monitoring and clinical evaluation during the first 72 hours after surgery.	—

Measure

Time frame

Incidence of premature atrial contractions (PAC) and premature ventricular contractions (PVC) within 72 hours after coronary artery bypass graft surgery. Timepoint: The time points of measurement are within 72 hours after coronary artery bypass graft surgery. Method of measurement: The variable is measured using continuous ECG monitoring and clinical evaluation during the first 72 hours after surgery.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmadreza Assareh

Ahvaz University of Medical Sciences

dr_assarreh@ajums.ac.ir+98 61 3339 4810

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026