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Comparison of the Effect of Povidone-Iodine and Metronidazole Gel in Vaginal Antisepsis Before Emergency Cesarean Section and Prevention of Postpartum Infections

Comparative Study of Vaginal Preparation Using Povidone-Iodine and Metronidazole Gel on Post-Cesarean Infections

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250225064853N2
Enrollment
150
Registered
2025-03-10
Start date
2025-03-21
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wound infection. Infection of obstetric surgical wound

Interventions

Intervention 1: Intervention Group 1:In this group, vaginal preparation will be performed using 10% Povidone-Iodine (Betadine). This antiseptic solution will be applied with a standard 10% concentrati

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women aged 18 to 40 years Candidates for emergency cesarean section (unplanned C-section) Providing informed consent and signing the participation form

Exclusion criteria

Exclusion criteria: Known allergy to Betadine or Metronidazole gel Presence of an active infection at the time of surgery Immunodeficiency or use of immunosuppressive drugs Pregnancy (if there is potential risk to the fetus) Breastfeeding (only if there is evidence of potential risk of material transfer to the infant). Underlying conditions that could affect study outcomes (e.g., diabetes, hypertension) Active infections or specific obstetric conditions (e.g., chorioamnionitis, active herpes, malpresentation, placenta previa, cord prolapse) Abnormal vaginal discharge

Design outcomes

Primary

MeasureTime frame
Rate of Postoperative Infection. Timepoint: 2 days after surgery. Method of measurement: Patient records and evaluation of infection symptoms (fever, purulent discharge, redness, and wound inflammation).;Duration of Hospital Stay. Timepoint: From admission to discharge post-surgery. Method of measurement: Recording the number of hospitalization days in the patient file.;Readmission Rate. Timepoint: Within 2 days post-surgery. Method of measurement: Documentation in the patient file and readmission reports.;Rate of Endometritis (Uterine Inflammation). Timepoint: 2 days after surgery. Method of measurement: Clinical symptom evaluation and documentation in the patient file.;Wound Dehiscence Rate. Timepoint: 2 days after surgery. Method of measurement: Physical examination by the physician and documentation in the patient file.

Secondary

MeasureTime frame
Postoperative Fever Rate. Timepoint: 2 days after surgery. Method of measurement: Recording the patient’s body temperature in the patient file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Shahshahan

Esfahan University of Medical Sciences

shahshahan@med.mui.ac.ir+98 31 3792 8134

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026