Melasma.
Conditions
Interventions
Intervention 1: Patients over 18 years of age with melasma who receive laser and tranexamic acid on one side of the face. Intervention 2: Control group: Patients over 18 years of age with melasma who
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The patient must be over 18 years of age. The patient has Fitzpatrick skin type II-IV with bilateral symmetrical Melasma. The patient has had Melasma for at least 6 months.
Exclusion criteria
Exclusion criteria: The patient is pregnant or breastfeeding. The patient has active herpes lesions and active infection in the area being treated with laser. Patients undergoing treatments such as alpha hydroxy acids, birth control pills, chemical peels, dermabrasion, tanning beds, or sunburn that affect skin pigmentation at the time of the study or within the past three months The patient has a history of hypersensitivity to topical medications, a personal or family history of vitiligo, or a history of laser therapy side effects and keloid formation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of patient satisfaction with the treatment. Timepoint: Before and after treatment. Method of measurement: Patient satisfaction questionnaire that provides patient satisfaction with the treatment outcome on a scale of 1-10.;Melasma treatment. Timepoint: Before and after treatment. Method of measurement: In this scoring system, the entire face is divided into four areas: forehead, right malar, left malar, and chin, representing 30, 30, 30, and 10% of the entire face, respectively. . Melasma severity was determined by three variables: percentage of total area involved, on a scale of 0 (no involvement) to 6 (90-100% involvement); darkness, on a scale of 0 (absent) to 4 (maximum); and homogeneity, hyperpigmentation, on a scale of 0 (minimal) to 4 (maximum). The MASI score on each side of the face will be calculated by a blinded rater at baseline and after the last session 2 weeks later with the equation: MASI = 0.3(DF+HF)AF+0.3(DMR+HMR)AMR+0.3(DML+HML)AML+0.1(DC+HC)AC. | — |
Secondary
| Measure | Time frame |
|---|---|
| . Timepoint: . Method of measurement: .;. Timepoint: . Method of measurement: . | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatima Alhjjar
Tehran University of Medical Sciences
Outcome results
None listed