Comparing the effect of N-acetylcysteine ??with sodium bicarbonate on secretion excretion

Comparison of the effect of using N-acetylcysteine with sodium bicarbonate in endotracheal tube suction on excrement excretion in patients under mechanical ventilation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250218064762N1

Enrollment

Registered

2025-06-29

Start date

2025-06-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway obstruction in mechanically ventilated patients caused by mucus plaque.. Other specified respiratory disorders

Interventions

Intervention group: Intervention group: Group A Bicarbonate, 3 ml of 4.2% bicarbonate was poured into the endotracheal tube with a 5 cc syringe and then connected to the ventilator. After 5 breaths, t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having an endotracheal tube or tracheostomy RDOS scale above 3 Active expiratory breathing pattern Reducing tidal volume High PIP airway pressure and high Pplat pressure depending on the type of ventilator mode (pressure and volume) Flow-time and flow-volume loops indicate airway obstruction.

Exclusion criteria

Exclusion criteria: Removal of the endotracheal tube before the end of the study 2.Patient death

Design outcomes

Primary

Measure	Time frame
The effect of N-acetylcysteine ??and sodium bicarbonate in endotracheal tube suction on relieving respiratory distress in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on capnometry results in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on blood oxygen saturation in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on changes in Pplat in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on changes in Ppeak in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and sodium bicarbonate on changes in flow-time curves and flow-volume loops in patients undergoing mechanical ventilation. Timepoint: The number of suctions is not fixed and suction is based on the patient's needs and the RDOS criterion is measured by the researcher 3 minutes after each suction and will continue until the RDOS criterion is <3 depending on the respiratory distress status. In this study, the amount of changes in graphs and loops, changes in PIP and Pplat according to the mode used, vital signs (pulse, systolic and diastolic blood pressure and respiratory rate) will be examined and recorded before and after suction. ABG control will be examined to determine the effects of bicarbonate absorption from the trachea and its effect on blood pH. Method of measurement: Sodium bicarbonate, how to measure group A / N-acetylcysteine, how to measure group B / Excretion, how to measure Respiratory Distress Observation Scale (RDOS) / Pplat changes, measuring unit in centimeters of water / blood oxygen saturation (SpO2), measuring unit in percent / End tidal co2 (Etco2), measuring unit in millimeters of mercury / Ppeak changes, measuring unit in centimeters of water / Flow-time curves (expiratory) / Flow-time curves, measuring unit with or without obstruction / Flow-volume loops, measuring unit with or without ob	—

Measure

Time frame

The effect of N-acetylcysteine ??and sodium bicarbonate in endotracheal tube suction on relieving respiratory distress in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on capnometry results in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on blood oxygen saturation in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on changes in Pplat in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and bicarbonate on changes in Ppeak in patients undergoing mechanical ventilation/The effect of N-acetylcysteine ??and sodium bicarbonate on changes in flow-time curves and flow-volume loops in patients undergoing mechanical ventilation. Timepoint: The number of suctions is not fixed and suction is based on the patient's needs and the RDOS criterion is measured by the researcher 3 minutes after each suction and will continue until the RDOS criterion is <3 depending on the respiratory distress status. In this study, the amount of changes in graphs and loops, changes in PIP and Pplat according to the mode used, vital signs (pulse, systolic and diastolic blood pressure and respiratory rate) will be examined and recorded before and after suction. ABG control will be examined to determine the effects of bicarbonate absorption from the trachea and its effect on blood pH. Method of measurement: Sodium bicarbonate, how to measure group A / N-acetylcysteine, how to measure group B / Excretion, how to measure Respiratory Distress Observation Scale (RDOS) / Pplat changes, measuring unit in centimeters of water / blood oxygen saturation (SpO2), measuring unit in percent / End tidal co2 (Etco2), measuring unit in millimeters of mercury / Ppeak changes, measuring unit in centimeters of water / Flow-time curves (expiratory) / Flow-time curves, measuring unit with or without obstruction / Flow-volume loops, measuring unit with or without ob

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Secondary

Measure	Time frame
Ventilator mode , Type of disease , History of addiction , Dehydration , Respiratory physiotherapy, Average body temperature , Ambient temperature , Diuretics (loop and thiazide) , Previous suction with distilled water or normal saline , Cough reflex , Level of consciousness , Age , Gender. Timepoint: In this study, secondary variables will be examined and recorded before suction. Method of measurement: Ventilator mode How to measure the type of mode set for the patient , Type of disease Unit of measurement Diagnosis of the disease for which he was hospitalized , History of addiction Unit of measurement Has or does not have , Dehydration Unit of measurement Changes in BUN/CR test , Respiratory physiotherapy Unit of measurement Has or has not been performed, Average body temperature Unit of measurement Degrees Celsius, Ambient temperature Unit of measurement Degrees Celsius, Diuretic drugs (loop and thiazide) Unit of measurement Has or has not been used, Previous suction with distilled water or normal saline Unit of measurement Has or has not had intervention , Cough reflex Unit of measurement Has or has not had , Level of consciousness based on the four score or Richmond Agitation-Sedation Scale (RASS) , Age Unit of measurement Years, Gender Unit of measurement Male or female.	—

Measure

Time frame

Ventilator mode , Type of disease , History of addiction , Dehydration , Respiratory physiotherapy, Average body temperature , Ambient temperature , Diuretics (loop and thiazide) , Previous suction with distilled water or normal saline , Cough reflex , Level of consciousness , Age , Gender. Timepoint: In this study, secondary variables will be examined and recorded before suction. Method of measurement: Ventilator mode How to measure the type of mode set for the patient , Type of disease Unit of measurement Diagnosis of the disease for which he was hospitalized , History of addiction Unit of measurement Has or does not have , Dehydration Unit of measurement Changes in BUN/CR test , Respiratory physiotherapy Unit of measurement Has or has not been performed, Average body temperature Unit of measurement Degrees Celsius, Ambient temperature Unit of measurement Degrees Celsius, Diuretic drugs (loop and thiazide) Unit of measurement Has or has not been used, Previous suction with distilled water or normal saline Unit of measurement Has or has not had intervention , Cough reflex Unit of measurement Has or has not had , Level of consciousness based on the four score or Richmond Agitation-Sedation Scale (RASS) , Age Unit of measurement Years, Gender Unit of measurement Male or female.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad reza parsa

Mashhad University of Medical Sciences

mr.parsaa1991@gmail.com+98 51 3846 7673

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026