Major Depressive Disorder. Major depressive disorder, recurrent severe without psychotic features
Conditions
Interventions
Intervention 1: Intervention group: 16 people aged 18 to 65 years with treatment resistant depressive disorder, have been gotten 0.5 mg per kilogram of body weight dissolved in 50 cc of normal saline.
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Major depression based on clinical interview and based on DSM-5 criteria and Hamilton B scale no psychotic feature Blood pressure within normal range
Exclusion criteria
Exclusion criteria: A history of one or more seizures without an obvious cause, Pregnancy and lactation Patients with clear suicidal thoughts requiring emergency hospitalization No interaction of ketamine with other drugs (memantine, oxycodone, ...) History of drug dependence or abuse in the past three months Serious and unstable physical diseases such as liver, kidney, digestive, respiratory, cardiovascular or thyroid diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression in Hamilton's questionnaire. Timepoint: Depression severity with Hamilton questionnaire before intervention and 1 hour, 1 and 2 weeks, as well as 1 and 2 months after intervention. Method of measurement: Hamilton's questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSepideh Jalali
Kashan University of Medical Sciences
Outcome results
None listed