Evaluating the effect of two pharmaceutical forms of probiotics on colonization by Candida Albicans in patients with complete denture.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250211064706N1

Enrollment

Registered

2025-04-10

Start date

2025-04-09

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

denture stomatitis.

Interventions

Intervention 1: Intervention group: The first experimental group was instructed to use 10 cc of Subular probiotic mouthwash containing 10^9 CFU of Lactobacillus reuteri (Goserat Milad Pharmed Company,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: No use of adhesives to stabilize dentures No antibiotic use in the past 30 days Absence of systemic disease that affects oral mucosal homeostasis (lupus erythematosus, lichen planus, xerostomia) Absence of systemic disease that affects the immune system (malignancies, transplant-related immunosuppressive therapies)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Number of Candida albicans colonies, groups studied, times studied. Timepoint: After 1 week, all patients will be examined for a second microbiological evaluation (T1) and after 2 weeks for a third microbiological evaluation (T2). Method of measurement: About 1 ml of saliva is poured into sterile containers and using a sampler, 1 ml of saliva is placed directly on Sabouraud dextrose agar medium containing chloramphenicol (50 mg/l). The plates are then kept at 37 degrees for 5 days. Each day, the isolated candidate colonies are examined and counted and the results are recorded in terms of the number of isolated colonies per milliliter (CFU/ml).	—

Measure

Time frame

Number of Candida albicans colonies, groups studied, times studied. Timepoint: After 1 week, all patients will be examined for a second microbiological evaluation (T1) and after 2 weeks for a third microbiological evaluation (T2). Method of measurement: About 1 ml of saliva is poured into sterile containers and using a sampler, 1 ml of saliva is placed directly on Sabouraud dextrose agar medium containing chloramphenicol (50 mg/l). The plates are then kept at 37 degrees for 5 days. Each day, the isolated candidate colonies are examined and counted and the results are recorded in terms of the number of isolated colonies per milliliter (CFU/ml).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hassan Akhavan Karbassi

Yazd University of Medical Sciences

dr.akhavankarbassi@ssu.ac.ir+98 35 3623 8506

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026