Study of the antibacterial effect of chitosan mouthwash against Streptococcus mutans in patients with removable orthodontic appliances

The anti-bacterial effect on Streptococcus mutans of chitosan mouth rinse in patients wearing orthodontic removable appliance

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250210064702N1

Enrollment

Registered

2025-03-21

Start date

2025-02-19

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Streptococcus mutans bacteria. Streptococcus, Staphylococcus, and Enterococcus as the cause of diseases classified elsewhere

Interventions

Intervention 1: Intervention group: Low molecular weight chitosan (75%<DD<85%,MW 107 kDa) and high molecular weight chitosan (75%<DD,MW 624 kDa) produced by Sigma-Aldrich, St. Louis, USA will be used

Eligibility

Sex/Gender

All

Age

9 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 9 years old

Exclusion criteria

Exclusion criteria: Active dental caries Periodontal diseases Systemic diseases Antibiotic use up to 3 months before study entry

Design outcomes

Primary

Measure	Time frame
Number of Streptococcus mutans colonies. Timepoint: Checking the number of colonies at the beginning of the study and one month after using the mouthwash. Method of measurement: After culturing the bacterial samples and incubation process, the number of bacterial colonies was counted using a digital colony counter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactValiollah Arash

Babol University of Medical Sciences

Valiarash44@gmail.com0981132258490

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026