Coronary artery disease. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, patients will receive 3 mg of melatonin tablets for 3 nights before the operation until the end of the day when they are in the cardiac s
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to No maximum
Inclusion criteria
Inclusion criteria: Elective coronary artery bypass surgery using on-pump (CABG) in Shahid Faqihi and Namazi hospitals in Shiraz Age above 30 years ASA: 1-3 GCS:15
Exclusion criteria
Exclusion criteria: Age less than 30 years Emergency surgery Valve surgery at the same time as coronary artery bypass surgery Off-pump surgery More than 4 coronary artery grafts Previous history of any cardiac arrhythmia Having a pacemaker Local or systemic infection Heart failure with an ejection fraction of less than 30% Uncontrolled blood pressure and diabetes History of seizures History of recent or chronic use of psychiatric drugs, sleeping pills, alcohol and melatonin Severe liver, kidney and lung diseases inability to speak malignancy Pregnancy and breastfeeding Allergy to melatonin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose of intravenous hypnotic drug. Timepoint: The first day after surgery. Method of measurement: Patient file.;Cardiac arrhythmia. Timepoint: During weaning from the cardiopulmonary pump. Method of measurement: Observation.;Duration of using mechanical ventilation. Timepoint: After surgery. Method of measurement: Observation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: Until discharge from ICU. Method of measurement: counting.;Length of stay in ICU. Timepoint: At the time of discharge from the ICU. Method of measurement: Counting. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahare Firouzbakht
Shiraz University of Medical Sciences
Outcome results
None listed