Evaluation of the efficacy of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma and a history of failed glaucoma filtration surgery.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250203064628N1

Enrollment

Registered

2025-02-19

Start date

2025-02-18

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Open angle glaucoma. Open-angle glaucoma

Interventions

Intervention 1: Intervention Group:The GATT procedure with approximately 2 mm of goniotomy using a micro vitrectomy blade will be initiated through a temporal paracentesis. A 6-0 or 5-0 polypropylene

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with OAG who have had glaucoma filtration surgery before IOP higher than the target range depending on the glaucoma stage despite the full topical anti-glaucoma medication Anatomic evidence (increased cupping or RNFL atrophy) of glaucoma progression despite the controlled IOP Functional evidence (Visual field defect worsening) of glaucoma progression despite the controlled IOP

Exclusion criteria

Exclusion criteria: Reluctance to continue participating in the study History of ocular trauma History of uveitis History of other ocular surgery except for the uncomplicated cataract surgery and the filtration surgery Age < 18

Design outcomes

Primary

Measure	Time frame
Evaluation and comparison of best corrected visual acuity (BCVA) before and after GATT surgery. Timepoint: Best corrected visual acuity (BCVA) will be measured at baseline before the intervention and at 1 week, and 1, 3, and 6 months after GATT surgery. Method of measurement: The best corrected visual acuity (BCVA) of patients would be measured using an E-Chart under the standard examination room condition (appropriate distance and light). The BCVA data of all the included patients in pre-op and post-op visits will be gathered from the hospital and the private clinic documents. The BCVA would be assessed by an optometrist who is blind to the study.;Evaluation and comparison of intraocular pressure (IOP) before and after GATT surgery. Timepoint: Intraocular pressure (IOP) will be measured at baseline before the intervention and at 1 week, and 1, 3, and 6 months after GATT surgery. Method of measurement: All the patients would undergo a thorough ophthalmic examination to have a wholistic evaluation of the target eye in each visit and determine their IOP by Goldmann applanation tonometry. The IOP would be double assessed by two separate ophthalmologists independently in each visit and the mean value would be used for the study.;Number of needed topical anti-glaucoma medication evaluation and comparison before and after the GATT surgery. Timepoint: The number of topical anti-glaucoma medications will be recorded at baseline before the intervention and at 1 week, and 1, 3, and 6 months after GATT surgery. Method of measurement: Included patients would be asked to declare any topical or oral anti-glaucoma medications in each visit and the list of the medications and the frequency of prescription would be submitted in the medical document. The number of needed topical anti-glaucoma medication in post-op visits would be compared to the pre-op one.	—

Measure

Time frame

Evaluation and comparison of best corrected visual acuity (BCVA) before and after GATT surgery. Timepoint: Best corrected visual acuity (BCVA) will be measured at baseline before the intervention and at 1 week, and 1, 3, and 6 months after GATT surgery. Method of measurement: The best corrected visual acuity (BCVA) of patients would be measured using an E-Chart under the standard examination room condition (appropriate distance and light). The BCVA data of all the included patients in pre-op and post-op visits will be gathered from the hospital and the private clinic documents. The BCVA would be assessed by an optometrist who is blind to the study.;Evaluation and comparison of intraocular pressure (IOP) before and after GATT surgery. Timepoint: Intraocular pressure (IOP) will be measured at baseline before the intervention and at 1 week, and 1, 3, and 6 months after GATT surgery. Method of measurement: All the patients would undergo a thorough ophthalmic examination to have a wholistic evaluation of the target eye in each visit and determine their IOP by Goldmann applanation tonometry. The IOP would be double assessed by two separate ophthalmologists independently in each visit and the mean value would be used for the study.;Number of needed topical anti-glaucoma medication evaluation and comparison before and after the GATT surgery. Timepoint: The number of topical anti-glaucoma medications will be recorded at baseline before the intervention and at 1 week, and 1, 3, and 6 months after GATT surgery. Method of measurement: Included patients would be asked to declare any topical or oral anti-glaucoma medications in each visit and the list of the medications and the frequency of prescription would be submitted in the medical document. The number of needed topical anti-glaucoma medication in post-op visits would be compared to the pre-op one.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad fallahi motlagh

Tabriz University of Medical Sciences

bfm1346@yahoo.com+98 41 3657 7330

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026