Endometrial Hypotrophy. Noninflammatory disorder of uterus, unspecified
Conditions
Interventions
Intervention 1: intervention group: Group 1 (ADSCs Group): Participants will receive intrauterine injections of autologous adipose-derived stem cells (ADSCs) obtained via minimal liposuction. The inje
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women aged 25 to 45 years. Diagnosis of endometrial hypotrophy (endometrial thickness =7mm). Candidates for frozen embryo transfer (FET). No history of endometrial cancer or severe uterine abnormalities. Willingness to provide informed consent for participation.
Exclusion criteria
Exclusion criteria: Presence of untreated uterine pathology (e.g., fibroids, polyps, adenomyosis). Known allergy or hypersensitivity to stem cell therapy or PRP. Severe systemic diseases or conditions contraindicating pregnancy. Participation in another clinical trial involving reproductive interventions. Patients who fail to adhere to study protocols or follow-ups
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrial thickness (measured in mm) before and after the intervention. Timepoint: Day 10 to 12 of the embryo transfer cycle (FET): Endometrial thickness (ET) assessmentIf ET = 7 mm (endometrial hypotrophy is confirmed): Administration of ADSCs or PRP48 hours after intervention: Re-evaluation of endometrial thickness. Method of measurement: Transvaginal ultrasound (TVUS) will be used to measure endometrial thickness. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include clinical pregnancy rate, implantation rate, biochemical pregnancy rate, and miscarriage rate.Comparison of ADSCs and PRP in improving endometrial receptivity and reducing miscarriage risk. Timepoint: on day 14 post-FET.Miscarriage assessment will be done throughout the first trimester. Method of measurement: Ultrasound assessment for implantation and endometrial receptivity.Serum ß-hCG levels for biochemical pregnancy detection.Follow-up of pregnancy viability and miscarriage confirmation by ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactfahimeh karimi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed