Postoperative pain. Postoperative pain
Conditions
Interventions
Intervention 1: Intervention group 1: Patients in this group will receive 30 mg of duloxetine capsules once daily before surgery and the same dose will be repeated until the day of surgery. A similar
Sponsors
Birjand University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 15 to 65 years, ASA class I and II, candidates for major orthopedic surgery, including surgery of the arm, thigh, leg, forearm, and elbow, which the surgery lasts more than half an hour.
Exclusion criteria
Exclusion criteria: Patients with a history of seizures, neuropathic pain of the lower extremities, neurological disorders, cardiac arrhythmia, liver and kidney failure and electrolyte disorders, multiple trauma, smokers, alcohol addiction, chronic use of opioids or antidepressants, pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of the first request for painkillers. Timepoint: After surgery. Method of measurement: Checklist.;Pain severity based on numeric rating scale criteria. Timepoint: 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Numeric rating scale criteria.;Average prescribed opioid and non-opioid analgesics. Timepoint: During the first 24 hours after surgery. Method of measurement: Checklist. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: During and after the surgery. Method of measurement: Checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahmoud Ganjifard
Birjand University of Medical Sciences
Outcome results
None listed