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Evaluating the Effectiveness of Brain Stimulation and Medications for Post-Stroke Aphasia

Comparison of the Effectiveness of Transcranial Direct Current Stimulation and Galantamine and Fluoxetine on Aphasia after Stroke

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250130064571N1
Enrollment
16
Registered
2025-03-06
Start date
2025-01-18
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia after stroke. Cerebral infarction, unspecified

Interventions

Intervention 1: Intervention group: Drug intervention with galantamine 16 mg per day and fluoxetine 20 mg per day for 12 weeks. After the drug intervention, transcranial direct current stimulation (tD

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
36 Years to 75 Years

Inclusion criteria

Inclusion criteria: The definitive diagnosis of stroke should be based on clinical and radiological criteria Aphasia following a stroke that has occurred at least six months ago Individuals who consent to participate in the study Individuals who have no serious memory deficits

Exclusion criteria

Exclusion criteria: Individuals who are in poor general condition Individuals who are allergic to galantamine and fluoxetine Individuals who do not wish to continue participating in the study

Design outcomes

Primary

MeasureTime frame
Aphasia score in the Persian WAB (P-WAB-1) questionnaire. Timepoint: Assessment of aphasia score at the beginning of the study (before starting the intervention), 3 months after using galantamine and fluoxetine, immediately after completing the real or sham brain stimulation. Method of measurement: Persian diagnostic aphasia battery bedside version (P-WAB-1).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Mahdi Talimkhani

Hamedan University of Medical Sciences

mahdi99talimkhani@gmail.com+98 81 3826 2435

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026