Blackberry Fruit in Hepatitis B Virus Infection

Investigating the effect of oral consumption of blackberry fruit concentrate (Morus nigra L) on the result of HBV PCR test in patients with hepatitis B virus infection in the immunotolerant and inactive phase

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250129064564N1

Enrollment

Registered

2025-03-15

Start date

2025-02-19

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with chronic HBV infection. Chronic viral hepatitis B without delta-agent

Interventions

Intervention 1: Intervention group: Blackberry fruit concentrate, will be prescribed as 200 CC daily for intervention group. HBV PCR viral load, Hbe Ag and liver enzymes will be checked for interventi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age More Than 18 Years Diagnosis of Chronic HBV Infection Patients in Inactive or Immunotolerant Phase

Exclusion criteria

Exclusion criteria: Pregnancy and Breastfeeding Acute Illness History of other Chronic Diseases (Diabetes Mellitus, Asthma, Autoimmune Diseases, Rheumatoid Arthritis, Cardiovascular Diseases) HBV-HDV Infection HBV- HIV Infection HBV- HCV Infection Drug History of Oral Anti HBV Infection During Past Three Months Allergy History to Blackberry Fruit

Design outcomes

Primary

Measure	Time frame
Decrease level of HBV PCR viral load more than one log. Timepoint: Before the intervention and two to four weeks after the intervention. Method of measurement: Polymerase chain Reaction.;Negative HBe Ag test in patients in immunotolerant phase. Timepoint: Before the intervention and two to four weeks after the intervention. Method of measurement: ELFA – CLIA/ECL.;Aminotransferases (AST, ALT). Timepoint: Before the intervention and two to four weeks after the intervention. Method of measurement: Immunoassay.	—

Measure

Time frame

Decrease level of HBV PCR viral load more than one log. Timepoint: Before the intervention and two to four weeks after the intervention. Method of measurement: Polymerase chain Reaction.;Negative HBe Ag test in patients in immunotolerant phase. Timepoint: Before the intervention and two to four weeks after the intervention. Method of measurement: ELFA – CLIA/ECL.;Aminotransferases (AST, ALT). Timepoint: Before the intervention and two to four weeks after the intervention. Method of measurement: Immunoassay.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Ahmadinejad

Tehran University of Medical Sciences

ahmadiz@tums.ac.ir+98 21 6658 1598

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026