Trauma brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: The first intervention group received a probiotic supplement containing 1×109 CFU of probiotic organisms for 10 days from Tekgen Zist Company. Intervention 2: Inter
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of brain trauma with CT scan and diagnosis by a specialist Diagnosis of severe brain trauma with a Glasgow Coma Scale between 3 and 8 Age 18 to 70 years Need for at least ten days of hospitalization in the intensive care unit with the diagnosis and prognosis of the relevant specialist Patient's hemodynamic stability
Exclusion criteria
Exclusion criteria: Pregnancy or lactation Previous major gastrointestinal; hematological; endocrine diseases; Immunosuppression; Pneumonia or other infectious diseases after admission; HIV positivity; cancer Use of probiotic or synbiotic supplements within the last month prior to study entry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein. Timepoint: Beginning of the study and the tenth day of the study. Method of measurement: Enzyme-linked immunosorbent assay.;Interleukin 6. Timepoint: Beginning of the study and the tenth day of the study. Method of measurement: Enzyme-linked immunosorbent assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythrocyte sedimentation rate. Timepoint: Beginning of the study and the tenth day of the study. Method of measurement: Westergren.;Assessing the level of consciousness. Timepoint: Beginning of the study and the tenth day of the study. Method of measurement: Glasgow Coma Scale.;Disease severity score. Timepoint: Beginning of the study and the tenth day of the study. Method of measurement: Acute Physiology and Chronic Health Evaluation II (APACHE II).;Organ failure in the intensive care unit. Timepoint: Beginning of the study and the tenth day of the study. Method of measurement: Sequential Organ Failure Assessment score (SOFA score).;Length of hospital stay. Timepoint: Study start and discharge time. Method of measurement: Patient file.;Mortality. Timepoint: 30 days after receiving interventions. Method of measurement: The discharge status of the patient as well as telephone follow-up 28days after receiving the intervention. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mohammad Aghaeinejad
Iran University of Medical Sciences
Outcome results
None listed