Effect of Ketotifen in the treatment of eczema

An Investigation of the effect of Ketotifen cream (0.1%, 0.2%) on patients with eczema

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250122064483N1

Enrollment

Registered

2025-02-15

Start date

2025-03-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eczema. Intrinsic (allergic) eczema

Interventions

Intervention 1: Intervention group: patients will receive ketotifen cream 1% topically, 3 times a day, for 2 months. Intervention 2: Intervention group: patients will receive ketotifen cream 2% topica

Eligibility

Sex/Gender

All

Age

1 Years to 55 Years

Inclusion criteria

Inclusion criteria: Patients between 1-55 years old Having atopic dermatitis confirmed by a dermatologist for at least two years Consent to participate in the study

Exclusion criteria

Exclusion criteria: Pregnancy or lactation Patients undergoing chemotherapy or radiotherapy History of allergy to ketotifen or other antihistamines Use of topical products other than moisturizers and hydrations in the past month

Design outcomes

Primary

Measure	Time frame
Skin redness. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Skin swelling. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Skin dryness. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Itching. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Skin thickening. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.	—

Measure

Time frame

Skin redness. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Skin swelling. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Skin dryness. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Itching. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.;Skin thickening. Timepoint: Before starting treatment (using topical cream) and two months after treatment. Method of measurement: Based on the observation and examination in four scales of: severe, moderate, poor, none.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahel Mohseni

Ahvaz University of Medical Sciences

s.mohseni1999@yahoo.com+98 916 827 7200

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026