Therapeutic results of minimal and scattered punch grafting combined with donor site abrasion and topical application of 5-fluorouracil solution in refractory vitiligo lesions

Investigating of outcome minimal scattered punch graft along with donor site abrasion and 5-Fu topical solution in vitiligenous resistant lesions.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250121064470N1

Enrollment

Registered

2025-02-04

Start date

2024-09-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. Vitiligo

Interventions

Intervention group: Combined treatment of topical 5-FU and microneedling is performed for patients. First, we perform processing on the depigmented lesions using a microneedling device, then Ebewe's 5

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Stable and resistant vitiligo patients Failure to respond to nonsurgical treatment within 6 months

Exclusion criteria

Exclusion criteria: Presence of other skin diseases such as psoriasis, eczema, infection Patients with allergies to lidocaine Pregnant and breastfeeding women

Design outcomes

Primary

Measure	Time frame
Repigmentation. Timepoint: Three weeks, two months, six months. Method of measurement: Photo before starting the procedure and after completing the treatment.	—

Secondary

Measure	Time frame
Repigmentation rate. Timepoint: Three weeks, two months, six months. Method of measurement: Before and after treatment photos.;Treatment site and pigmentation improvement. Timepoint: Three weeks, two months, six months. Method of measurement: Before and after treatment photos.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHazhir Mehrabani

Kermanshah University of Medical Sciences

sepehr.amiri1398@gmail.com+98 83 3827 6879

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026