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Effect of Midazolam premedication on postanesthetic recovery profiles following orthognathic surgery: A randomized clinical trial

Effect of Midazolam premedication on postanesthetic recovery profiles following orthognathic surgery: A randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250118064423N1
Enrollment
60
Registered
2025-04-07
Start date
2023-07-23
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Agitation. Condition 2: Shivering. Condition 3: Nausea severity. Condition 4: Surgery reminder. Restlessness and agitation Tremor, unspecified Nausea Other symptoms and signs involving cognitive functions and awareness

Interventions

Intervention 1: Intervention group: Those receiving intravenous midazolam. The surgeon, the project implementation assistant, was unaware of the contents of the injected drug. After informed consent f

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients undergoing orthognathic surgery under general anesthesia Patients aged 18-50 years Non-smoker Surgery and anesthesia duration less than 5 hours Has American Society of Anesthesiologists (ASA) physical condition class l-ll

Exclusion criteria

Exclusion criteria: Those who are severely obese (body mass index >= 35 kg/m2). Smokers Those with a history of postoperative nausea and vomiting (PONV) or motion sickness. People who have experienced nausea or vomiting 24 hours before the procedure. Patients taking psychotropic medications (benzodiazepines, antidepressants, antiepileptics, and antipsychotics) Patients with a history of depression, cirrhosis, heart failure, and renal failure.

Design outcomes

Primary

MeasureTime frame
Agitation. Timepoint: When entering the recovery room until discharge from recovery. Method of measurement: Scored by the recovery nurse through the ratings specified in the checklist.;Shivering. Timepoint: When entering the recovery room until discharge from recovery. Method of measurement: Scored by the recovery nurse through the ratings specified in the checklist.;Severity nausea post operating. Timepoint: When entering the recovery room until discharge from recovery. Method of measurement: Scored by the recovery nurse through the ratings specified in the checklist.;Surgery reminder. Timepoint: When entering the recovery room until discharge from recovery. Method of measurement: Scored by the recovery nurse through the ratings specified in the checklist.

Secondary

MeasureTime frame
Length of stay in recovery. Timepoint: From the time you enter the recovery room until you are discharged from recovery. Method of measurement: The patient's entry and exit time is measured by the recovery nurse.;Amount of bleeding during surgery. Timepoint: From the time you enter the recovery room until you are discharged from recovery. Method of measurement: The recovery nurse measures the volume of bleeding using a special suction graduated glass.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Modaberi

Shiraz University of Medical Sciences

drali.modaberi2024@gmail.com+98 910 200 7306

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026