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Efficacy of vaginal Dexamethasone in cervical preparation

Comparison of the effectiveness of vaginal dexamethasone and placebo in preparing the cervix for induction of labor in primiparous pregnant women

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250118064418N1
Enrollment
100
Registered
2025-03-01
Start date
2025-02-08
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of labor with dexamethasone.

Interventions

Intervention 1: Intervention group: Dexamethasone tablets labeled as Tablet A are delivered by a non-interventionist in the study. Dexamethasone is administered in the amount of 8 mg in the form of 2

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Primiparous pregnant mother singleton pregnancy full pregnancy (37 weeks and 6 days and more) age between 18 and 35 years normal body mass index 18.5 to 24.9 the fetus must be in cephalic position Bishop's score =4 estimated fetal weight of 2500-4000 grams the gynecologist and obstetrician make the patient a candidate for termination of pregnancy

Exclusion criteria

Exclusion criteria: If the pregnant woman use any hormones or herbal medicines (traditional medicines), herbal/natural products, or conventional/prescribed medicines during her pregnancy Those with the following pre-existing conditions, including diabetes, high blood pressure, a history of obstetric complications such as preeclampsia or eclampsia, or HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) Those with a previous presentation with fetal inactivity/decreased fetal movements Those with a previous presentation with a history of maternal hemorrhage

Design outcomes

Primary

MeasureTime frame
Cervical preparation rate for labor induction in primiparous pregnant mothers. Timepoint: During labor, the first minute, and the fifth minute after delivery. Method of measurement: Cervical preparation dosage form for labor induction.

Secondary

MeasureTime frame
Newborn Apgar score. Timepoint: The first and fifth minutes after birth. Method of measurement: The Apgar score, also known as APGAR, is an acronym for 5 criteria that are each examined separately: Skin color (Appearance), Pulse or heart rate (Pulse), Reflex reactions (Grimace), Muscle tone or consistency (Activity), and Respiration.;Bishop Score. Timepoint: The initial visit of the pregnant woman and entry into the study and during delivery. Method of measurement: Based on 5 components of dilation, effacement, consistency, cervical position, and organ position, demonstrated through pelvic examination, each of which is given a score from 0 to 3.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSetareh Jami

Zahedan University of Medical Sciences

setarehjami9111@gmail.com+98 915 763 6126

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026