Hemodialysis. Chronic kidney disease (CKD)
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will consume two synbiotic capsules with the brand name Lactocare (500 mg) daily, one after lunch and the other after dinner, for eight weeks
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Consent and interest in participating in the study Age 18 - 65 years old Hemodialysis treatment at least twice a week for a maximum of four hours each time Undergoing hemodialysis treatment for at least six months Presence of uremic pruritus as diagnosed by a doctor for at least six months and obtaining a score of at least mild on the YOSIPOVITCH questionnaire Experiencing muscle cramps at least once a week Life expectancy and survival for at least three months
Exclusion criteria
Exclusion criteria: Kidney and organ transplant candidates Consuming synbiotics, probiotics, prebiotics, or antibiotics four weeks before participating in the study Having a severe infection within four weeks before study participation Chronic liver disease (hepatitis B, hepatitis C), pulmonary, cardiovascular, acute pancreatitis, gastrointestinal disorders (inflammatory bowel disease, ulcerative colitis, Crohn's, celiac disease, lactose intolerance or allergy, irritable bowel syndrome), active cancers, immunodeficiency, HIV
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uremic pruritus severity. Timepoint: The severity of uremic pruritus will be measured before and after the intervention. Method of measurement: YOSIPOVITCH Itch Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle cramps. Timepoint: Muscle cramps will be measured before and after the intervention. Method of measurement: Visual analog scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahein Momenabadi
Semnan University of Medical Sciences
Outcome results
None listed