Studying the effectiveness of probiotics on IVF success rates

Studying the effectiveness of probiotics (Lactofem) on IVF success rates compared to placebo

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250115064391N1

Enrollment

Registered

2025-01-24

Start date

2025-02-19

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Repeated implantation failure. Complications of attempted introduction of embryo in embryo transfer

Interventions

Intervention 1: Intervention group: Starting 4 weeks before IVF, 1 capsule of Lactofem orally daily. Made by Zist Takhim Company. Intervention 2: Control group: 1 placebo capsule orally daily starting

Eligibility

Sex/Gender

Female

Age

20 Years to 44 Years

Inclusion criteria

Inclusion criteria: Normal uterine cavity Repeated implantation failure Informed consent

Exclusion criteria

Exclusion criteria: Unwillingness to continue participating in the trial Life-threatening complications (e.g. anaphylaxis) History of allergy to any of the product components Presence of chronic disease and treatment Presence of endometrial pathology identified on ultrasound Presence of hydrosalpinx

Design outcomes

Primary

Measure	Time frame
Chemical pregnancy. Timepoint: 2 weeks after IVF. Method of measurement: Bhcg level blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Motamedi

Esfahan University of Medical Sciences

Mahnazmotamedi94@gmail.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026