Investigating the effect of licorice mouthwash on the treatment of Moderate Gingivitis

Comparison of the Effect of a Hydroalcoholic Licorice Mouthwash Versus a Placebo Mouthwash on the Reduction of Gingival Inflammatory Indices in Patients with Moderate Gingivitis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250113064371N2

Enrollment

Registered

2026-05-27

Start date

2026-03-21

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate Gingivitis. Chronic gingivitis

Interventions

Intervention 1: Intervention group: Hydroalcoholic licorice root mouthwash at 20% concentration, used twice daily (morning and evening) for two weeks. In each session, 5 milliliters of mouthwash is ri

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Gingival Index (GI) according to Löe and Silness ranging from 1.1 to 2.0, bleeding on probing (BOP) of 30–60% Plaque Index (PI) between 1.1 and 2.0

Exclusion criteria

Exclusion criteria: Presence of any systemic disease Pregnant or breastfeeding women Individuals receiving any medications or those who have used antibiotics within the past three months History of hypersensitivity or allergy to antibiotics Individuals who have undergone scaling within the past six months Individuals who have had periodontal (gingival) surgery within the past six months Smokers

Design outcomes

Primary

Measure	Time frame
"Mean Gingival Index (GI) of patients at the end of the third week after the intervention". Timepoint: baseline (before starting the mouthwash) and at the end of the third week after the intervention. Method of measurement: Gingival Index will be measured using a Williams periodontal probe at the mesiobuccal, midbuccal, and distobuccal areas of each tooth, and the mean value will be calculated.;Probing Pocket Depth. Timepoint: baseline (before starting the mouthwash) and at the end of the third week after the intervention. Method of measurement: "Probing pocket depth will be measured using a Williams periodontal probe with the walking probe technique at six sites of each tooth, and the mean depth of each tooth and then the mean of all teeth for each patient will be calculated.".;Bleeding on Probing. Timepoint: baseline (before starting the mouthwash) and at the end of the third week after the intervention. Method of measurement: Using a blunt-tipped periodontal probe with gentle finger pressure, a sweeping motion is applied from the papilla base along the mesial-distal direction of each tooth, and bleeding intensity at each tooth surface is recorded and graded.	—

Measure

Time frame

"Mean Gingival Index (GI) of patients at the end of the third week after the intervention". Timepoint: baseline (before starting the mouthwash) and at the end of the third week after the intervention. Method of measurement: Gingival Index will be measured using a Williams periodontal probe at the mesiobuccal, midbuccal, and distobuccal areas of each tooth, and the mean value will be calculated.;Probing Pocket Depth. Timepoint: baseline (before starting the mouthwash) and at the end of the third week after the intervention. Method of measurement: "Probing pocket depth will be measured using a Williams periodontal probe with the walking probe technique at six sites of each tooth, and the mean depth of each tooth and then the mean of all teeth for each patient will be calculated.".;Bleeding on Probing. Timepoint: baseline (before starting the mouthwash) and at the end of the third week after the intervention. Method of measurement: Using a blunt-tipped periodontal probe with gentle finger pressure, a sweeping motion is applied from the papilla base along the mesial-distal direction of each tooth, and bleeding intensity at each tooth surface is recorded and graded.

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Secondary

Measure	Time frame
Presence of Adverse Effects. Timepoint: At the beginning of the study (before the intervention) and three weeks after starting the mouthwash use. Method of measurement: Side effects, including tooth discoloration, oral mucosal irritation or burning, dry mouth, and allergic reactions, will be recorded continuously through patient interviews and clinical examination. The type and severity of each adverse effect will be documented qualitatively in the patient’s record.	—

Measure

Time frame

Presence of Adverse Effects. Timepoint: At the beginning of the study (before the intervention) and three weeks after starting the mouthwash use. Method of measurement: Side effects, including tooth discoloration, oral mucosal irritation or burning, dry mouth, and allergic reactions, will be recorded continuously through patient interviews and clinical examination. The type and severity of each adverse effect will be documented qualitatively in the patient’s record.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Malmir

Babol University of Medical Sciences

f.malmir80@gmail.com+98 996 130 1939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026