Recurrent Aphthous Stomatitis. Recurrent oral aphthae
Conditions
Interventions
Intervention 1: Intervention group: Patients suffering from minor aphthous oral ulcers will be instructed to take one capsule every 12 hours (two capsules per day) on an empty stomach until their ora
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The presence of minor aphthous ulcers in the oral mucosa of the lips or cheeks for a minimum of four episodes per year
Exclusion criteria
Exclusion criteria: Systemic disease causing oral ulcers History of receiving chemotherapy, immunosuppressants, or corticosteroids within the past year Patients with other mucosal lesions Pregnant and breastfeeding women Patients undergoing treatment with anticoagulant medications Patients whose normal healing of aphthous ulcers typically occurs in less than 5 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound area. Timepoint: All patients in both periods are examined by a specialist in oral and dental diseases on the first, third, fifth, and seventh days. If healing of the lesions occurs at any time prior to these examinations, subsequent assessments will not be conducted. In the absence of healing by the seventh day, the use of the capsule or placebo will continue, and the patient will be re-examined on the tenth day. Method of measurement: Measurement of the wound diameter in patients will be conducted using an Iwanson gauge with an accuracy of one-tenth of a millimeter, recording both the maximum and minimum diameters. Subsequently, the area of the wound will be calculated using a mathematical formula based on the shape of the wound (circular or elliptical).;Pain. Timepoint: All patients in both periods are examined by a specialist in oral and dental diseases on the first, third, fifth, and seventh days. If healing of the lesions occurs at any time prior to these examinations, subsequent assessments will not be conducted. In the absence of healing by the seventh day, the use of the capsule or placebo will continue, and the patient will be re-examined on the tenth day. Method of measurement: Pain will be evaluated using the VAS (Visual Analog Scale) as a numerical measure from 0 to 10. For the patient, the number zero will be described as a state of no pain, while the number ten will represent the most severe pain experienced. In order to standardize the pain-inducing stimulus among patients, unsweetened orange juice (single-use) will be utilized.;Duration of Recovery. Timepoint: All patients in both periods are examined by a specialist in oral and dental diseases on the first, third, fifth, and seventh days. If healing of the lesions occurs at any time prior to these examinations, subsequent assessments will not be conducted. In the absence of healing by the seventh day, the use of the capsule or placebo will continue, and the patient will be re-examined on the | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSobhan Cholaki
Babol University of Medical Sciences
Outcome results
None listed