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The effect of ondansetron, pethidine, and dexmedetomidine on postoperative shivering.

Comparing Ondansetron, Pethidine, Dexmedetomidine as adjuant therapy to neuroaxial Marcaine 5% in postoperative shivering in patients undergoing TURP

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250112064367N1
Enrollment
81
Registered
2025-02-06
Start date
2025-03-21
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative shivering in patients undergoing TURP.

Interventions

Intervention 1: Group 1:Patients will receive 75 mg of Bupivacaine (Exir Pharmaceutical, Iran) combined with 1–1.5 cc of Ondansetron (Caspian Tamin Pharmaceutical, Iran) via the neuraxial route. Inter

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
35 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients undergoing TURP referred to Vali-Asr and Amir Al-Momenin Hospitals in Arak. Patients with informed consent for participation in the study. Patients aged 35 to 70 years Patients classified as ASA Class I and II Patients with no cardiovascular, respiratory, or renal diseases. Patients with no history of cerebrovascular accident (CVA). Patients who are not IV drug abusers All patients undergoing spinal anesthesia No allergy to Marcaine, Ondansetron, Pethidine, or Dexmedetomidine.

Exclusion criteria

Exclusion criteria: All patients for whom spinal anesthesia fails during surgery, requiring conversion to general anesthesia. All patients who experience cardiopulmonary arrest for any reason during surgery. All patients who, for any reason, require general anesthesia.

Design outcomes

Primary

MeasureTime frame
The occurrence or absence of shivering in patients. Timepoint: The occurrence of shivering and pain score in patients at 2, 4, 6, and 8 hours postoperatively. Method of measurement: VAS questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasoul Jafari

Arak University of Medical Sciences

Fateme.akhavan2021@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026