Gestational diabetes in pregnant women with obesity. Other and unspecified metabolic disorders
Conditions
Interventions
Intervention 1: Intervention group: Participants in the intervention group, after the initial measurement of inflammatory and oxidative stress factors, will start treatment with metformin. They will b
Sponsors
Yasouj University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: gestational age between 12-16 weeks single pregnancy Body mass index over 30
Exclusion criteria
Exclusion criteria: Abnormality in anomaly scan Allergy to metformine Diagnosis of gestational diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Antioxidant Capacity (TAC) of Plasma. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Serum concentrations of nitrite metabolites. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Protein Sulfhydryl. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Protein carbonyl. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Malondialdehyde (MDA) concentration. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Superoxide Dismutase (SOD) Activity. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Serum concentrations of nitrate metabolites. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mas index. Timepoint: Before and after intervention. Method of measurement: Scales and meters. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFateme Esameilpour
Yasouj University of Medical Sciences
Outcome results
None listed