The Effect of Curcumin and Vitamin D Supplementation on Inflammatory Biomarkers and Nutritional Status in Patients with Colorectal Cancer: A Randomized Clinical Control Trial

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250110064340N1

Enrollment

Registered

2025-03-27

Start date

2025-02-28

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer. Malignant neoplasm of colon

Interventions

Intervention 1: First intervention group: Curcumin group: They will receive 2 capsules of 40 mg of nano-curcumin daily (80 mg daily) and one vitamin D placebo weekly for 8 weeks. Manufacturer: Exir Na

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with colorectal cancer 18-60 years of age At least 3 months of life expectancy Using chemotherapy BMI=18-30 kg/m2 Nonallergic to turmeric Not suffering from hypertension or renal, hepatic, or parathyroid disorders

Exclusion criteria

Exclusion criteria: Unwillingness to participate in the study Not continuing chemotherapy Fever greater than 38.5°C in three days before receiving the first dose of the supplementary drugs Known positive HIV serology Patients with other malignancies, Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Tumor necrosis factor alpha. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using laboratory kit and ELISA method.;Interleukin 6. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using laboratory kit and ELISA method.;C-reactive protein to albumin ratio. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using a laboratory kit.;Hand muscle strength. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using handgrip.;Quality of life. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Quality of life questionnaire.;Body mass index, basal metabolic rate, fat mass, fat-free mass, weight. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using BIA.;Dietary components include energy, carbohydrates, protein, fat, and fiber. Timepoint: At the beginning of the study (before the intervention), 4 weeks after taking curcumin and vitamin D and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using a 24-hour food recall questionnaire.	—

Measure

Time frame

Tumor necrosis factor alpha. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using laboratory kit and ELISA method.;Interleukin 6. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using laboratory kit and ELISA method.;C-reactive protein to albumin ratio. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using a laboratory kit.;Hand muscle strength. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using handgrip.;Quality of life. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Quality of life questionnaire.;Body mass index, basal metabolic rate, fat mass, fat-free mass, weight. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using BIA.;Dietary components include energy, carbohydrates, protein, fat, and fiber. Timepoint: At the beginning of the study (before the intervention), 4 weeks after taking curcumin and vitamin D and 8 weeks after taking curcumin and vitamin D. Method of measurement: Using a 24-hour food recall questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Zamani

Shiraz University of Medical Sciences

mzamani.dmm@gmail.com+98 71 3725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026