evaluation of effect of melatonin in treatment of acute kidney injury

evaluation of melatonin effect on duration of increase in glomerular filtration rate in children with acute kidney injury: survival analysis model

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250110064339N1

Enrollment

124

Registered

2025-02-27

Start date

2025-04-20

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney failure. Acute kidney failure

Interventions

Intervention 1: Intervention group: In the intervention group, in addition to routine treatment, patients receive oral melatonin tablets once a day (30 to 60 minutes before bedtime at night) in differ

Eligibility

Sex/Gender

All

Age

3 Years to 18 Years

Inclusion criteria

Inclusion criteria: All children aged 3-18 years with acute kidney injury admitted to Amirkabir Hospital, Arak Filling out the informed consent form

Exclusion criteria

Exclusion criteria: post renal acute kidney injury Lack of confidence in the patient taking medications correctly

Design outcomes

Primary

Measure	Time frame
Assessing kidney function with glomerular filtration rate. Timepoint: Glomerular filtration rate measurement at the beginning of the study and 2, 4, and 6 days after entering the study. Method of measurement: blood sample.	—

Secondary

Measure	Time frame
Blood sodium. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Potassium. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Calcium. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Bicarbonate. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Blood sugar. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.	—

Measure

Time frame

Blood sodium. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Potassium. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Calcium. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Bicarbonate. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.;Blood sugar. Timepoint: at the beginning of the study and 2,4 and 6 days after entering the study. Method of measurement: blood sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazanin Moeini

Arak University of Medical Sciences

n.moeini@arakmu.ac.ir+98 86 3313 6055

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026