Investigating the Effect of Colistin with and without Ampisulbactam in Ventilator-Induced Pneumonia

Investigating the Effect of Colistin with and without Ampisulbactam on Acinetobacter isolates in Ventilator-Induced Pneumonia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250109064326N1

Enrollment

Registered

2025-06-20

Start date

2025-01-04

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated pneumonia. Pneumonia due to other aerobic Gram-negative bacteria

Interventions

Intervention 1: Intervention group1: 30 patients over 18 years of age with ventilator-associated pneumonia with positive Acinetobacter culture were treated with intravenous colistin (produced by Exir

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age>18 Ventilator-associated pneumonia Respiratory secretions culture result, Acinetobacter Mechanical ventilation for 48 hours or more

Exclusion criteria

Exclusion criteria: Polymicrobial ventilator-associated pneumonia Need for other gram-negative antibiotics for treatment Ventilator-associated pneumonia without microbiological findings

Design outcomes

Primary

Measure	Time frame
Body temperature. Timepoint: At the beginning of the study and on days 3 and 6 after the start of treatment. Method of measurement: Thermometer.;Serum creatinine level. Timepoint: Start of treatment and days of hospitalization. Method of measurement: CBC.;Time to wean from ventilator. Timepoint: With the start of treatment and daily check-ups. Method of measurement: Normalization of breathing rate and reduction of body temperature.	—

Measure

Time frame

Body temperature. Timepoint: At the beginning of the study and on days 3 and 6 after the start of treatment. Method of measurement: Thermometer.;Serum creatinine level. Timepoint: Start of treatment and days of hospitalization. Method of measurement: CBC.;Time to wean from ventilator. Timepoint: With the start of treatment and daily check-ups. Method of measurement: Normalization of breathing rate and reduction of body temperature.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ebrahim Ramadan Khani

Yazd University of Medical Sciences

e.ramezani501@gmail.com+98 35 3822 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026